ID A0A452SSD5_URSAM Unreviewed; 594 AA.
AC A0A452SSD5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN Name=EIF2A {ECO:0000313|Ensembl:ENSUAMP00000035694.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000035694.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000035694.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993,
CC ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
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DR AlphaFoldDB; A0A452SSD5; -.
DR STRING; 9643.ENSUAMP00000035694; -.
DR Ensembl; ENSUAMT00000039740.1; ENSUAMP00000035694.1; ENSUAMG00000027103.1.
DR GeneTree; ENSGT00730000111053; -.
DR OMA; WNPNSKE; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005850; C:eukaryotic translation initiation factor 2 complex; IEA:Ensembl.
DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:Ensembl.
DR GO; GO:0042255; P:ribosome assembly; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 225..420
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 442..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 66091 MW; E30700BFC774073A CRC64;
HAFSVAQDSA PLTPVLFKVR GSEGLYMVNG PPHFTESALF PRESGKNCKV YTFSKDGTLF
AWGNGEKINV INVTNKGLLH SFDLPKAVCL EFSPKNTILA TWQPYTTSKD GTAGIPNLQL
YDVKTGTCLK SFIQKKMQNW CPSWSEDESI CARNVNNEVH FFENNNFNTI ANKLHLQKIN
DFVLSPGPQP YKVAVYVPGS KGAPSFVRLY QYPNFDGPHA ALANKSFFKA DKVTMLWNKK
ATAVLVIAST DVDKTGASYY GEQTLHYIAA NGESAVMQLP KNGPIYDVVW NSSSTEFCAV
YGFMPAKATI FNLKCDPVFD FGTGPRNAAY YSPHGHILVL AGFGNLRGQM EVWDVKNYKL
ISKPVASDST YFAWCPDGEH ILTATCAPRL RVNNGYKIWH YTGSVLHKYD VPSNGELWQV
SWQPFLDGIF PVKTITYQAV RSDVPSEEPK VATAYRPPAL RNKPVTNSKL HEEEPPQNMK
PQAGNDKPLS KTALKNQRKH EAKKAAKQEA RNEKSPDLAP TPAPQSTPRN TVSQSTSGDP
EIDKKIKNLK KKLKAIEQLK EQAAAGKQLE KNQLEKIQKE KALLQELEDL ELGI
//
