ID A0A452STQ6_URSAM Unreviewed; 2385 AA.
AC A0A452STQ6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Collagen type VI alpha 5 chain {ECO:0000313|Ensembl:ENSUAMP00000036222.1};
GN Name=COL6A5 {ECO:0000313|Ensembl:ENSUAMP00000036222.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036222.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000036222.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9643.ENSUAMP00000036222; -.
DR Ensembl; ENSUAMT00000040308.1; ENSUAMP00000036222.1; ENSUAMG00000027447.1.
DR GeneTree; ENSGT00940000162990; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR CDD; cd01472; vWA_collagen; 2.
DR CDD; cd01450; vWFA_subfamily_ECM; 4.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 9.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF4; COLLAGEN ALPHA-5(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF00092; VWA; 9.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF53300; vWA-like; 10.
DR PROSITE; PS50234; VWFA; 9.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..2385
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019039449"
FT DOMAIN 30..206
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 259..436
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 465..635
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 651..820
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 837..1014
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1028..1205
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1516..1661
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1721..1912
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2047..2241
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 2018..2038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2018..2033
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2385 AA; 267017 MW; 27FF99A7BE3C7342 CRC64;
MKSLLIIFVL TLWTETLADQ SPEPGPEYAD VVFLVDSSDH LGTKSFPLVK AFIHKTVSGL
PVDAHKYRVA LAQYSDRLHS EFQLATFKSR NPMLNHLKKN FGFLGGSLRT GHALREAHRT
FFSAPAGGRD KKQFPPILVV LASAQSEDDV EEASKALRED GVRIVSVGLQ SASEEELKAM
ATARFHFNLR SARDLDAFSQ NMTQIIKEAT QYRDGAAPHS VDGKEGLGPM QAALRAPSSP
AARVLLSVIL ACQKDSLADL IFLVDESVGT KQNLRNLQNF LRNIAASMDV RYNCTRLGLM
SYSDRTNTIS LLNSSTTQYE FQEQIQKLSV QAGKSNAGAA IEKMRLEAFS ESSGSRRAQG
VPQIAVLVTH RPSTDEVRDV AIQLRLQDVT VFGMNIQGAD ETQLEEIASY PPRQMVSMLK
SYADLETYSK NFQKKLRNEI WSQISTRAEQ MDLDRTGCID TKEADIYFLI DGSTSIQGKH
FEQIKEFMLA VTGMFSIGPD KVQVGAVQYS HKMRVEFYIN DNSNNVNLKN AILNIEQLQG
NTYTGEALNF MLSIIKEDKK HRTSQVPCYL IVLTDGRSAD DVLEPAERLR AEQVTIHAVG
IGEANKVQLQ QIAGGEERVS FGQNFDSLRS IKNEVVHRIC TEKGCEDMKA DIMFLVDSSG
SIGHENFGKM KTFMKSLLAK IQIGPDRTHI GVIQFSDKTR EEFQLNKYFT QNEISDAIDR
MSLIDENTLT GNALISVDQY FTPARGARIG VKKFLILITD GEAQDAVRDP AKALRDKGVV
IFSVGVYGAN RTQLEEISGD GNLVFQVENF DDLKTIESKL IFRVCTLHDC KNIKVLDIVF
VLDHSGSINT QEQENMMALT IHLVKKADVG SDRVRIGALK YSDYPEILFH LGKYSNRSSV
IEHLRRRRDT GGNTYTARAL DHTNIMFTEE YGSRIQQNVK QMLIVITDGA SHDRTLLNET
ALKLRNRGID IYAVGVGPAD QLELEAMAGN KSKTFHVDNF NKLEDIYLPL QESMCINAHE
WCDIQEADVV FFCDGSDMVS NSEFVTMTTF VSELIDHFNI QNQKIKIGLA QFGSGFQKII
ELKNSLTIPE LKTQIQSIPK SKGFPRMDLA LKKVKAMFDP SSGGRRNAGV PQTLVVITSG
DPYYDVADEV KILRNLGICV LVWGIGNIHK EQLLPITGHS EKIVTLQDFN KLMNVDVKKR
MVREICQSCG KTNCFMDIVV GFDISTHLRG QPLFHGHPRL RSYLPGILED ISSIGRVSCG
AGSDVQVNVA FKVNNDREFP AKFQIYQKAI FDSLLQVTVN GPSHLNAQFL QSLWDTFKDQ
SKSQGQVLLI FSDGLGGESE IMLENQSDRL REAGLDALLV VSLNTTAHDE FSSFEFGKGF
DYMTHLTIGM RELGKMLSQY LGNVAEKTCC CTFCKCSGTP GPYGSRGLQA AKVPFRCETH
PGCLDLVGGT KAKGCTSQPS LDADEIASGI YFVRFLWCRS HCTPGVKGMG RTFDQQNNFI
LLLFMFAGTC PVYPTELVFA LDQSYGISEQ RFNEMREIVT SIVNDLNIKE SNCPVGARVV
VVSYDSGTSY LIRRSDYRNK KQLLQLISQI KYRPPTEARD VGNAMRFVAR NVFKRTYAGA
NVRKVAVFFS NGQAASRSSI ITATMEFSAL DISPAVFALN ERIFLEAFEF DNTGTFQVIP
VSPNGEYEPL EKFQHCTLCY DKCFPNECIK EIFLPEDAYM DVAFLLDNSQ TIANDEFKAV
KTLVSSMIDN FKIASDPGIS NFGDRIALLS YSPWDRSRKK KGVVKTEFGF TTFNDGVLMK
RHIQSSLRQL EGETTIGHTL LWVVENLFPQ TPNLRKHKVL FVISAGEYHE RKEFLKKVAL
RAKCQGYVIV VISLGSTYKE DMEELASYPL DHHLIQLGRI HKPDLDYITK FIRPFVYSVR
RGFNEYPPPV LENDCRLISR GEAYQNSDPL LTPEPHEISS GENSFIGQEL SAGKDSSFLW
EDNGSAHLVY VPSRVLTPQE LTITYAQDWD SEEIASLTSG HENHGRKEEP GLTNEPGDTS
LQEYYMDVAF LIDASQRIGN DEFKEVKAFL ISVLDYFHIA PDPLTSMLGD RVAVLSYSPP
GYMPNSEECP VYLEFDLVTY NSIHQMKHHL QDSFQQLNGD VFIGHALQWT IKNVFVGTPN
LRKNKVIFVI SAGETNPLDK EVLRNVALRA KCQGYSIFVF SFGPIHNDKE LEELASHPLD
HHLVQLGRTH KPDLNYITKF VKPFVHLIRR AINKYPPADL RPKCVNITSP NPENVGSGNN
VFLIPEVYKI ETGNSELFDE FGSQEQHSLV LGNNPSNGSE TTTDLIQKLY MLFSTGELVM
NDKEETHSEE MPALADGKLD KKGNLGYNGI KDPEVPLFRF SPGGR
//
