ID   A0A452STS8_URSAM        Unreviewed;       175 AA.
AC   A0A452STS8;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=NIPA like domain containing 1 {ECO:0000313|Ensembl:ENSUAMP00000036373.1};
GN   Name=NIPAL1 {ECO:0000313|Ensembl:ENSUAMP00000036373.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036373.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000036373.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the NIPA family.
CC       {ECO:0000256|ARBA:ARBA00007230}.
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DR   AlphaFoldDB; A0A452STS8; -.
DR   Ensembl; ENSUAMT00000040476.1; ENSUAMP00000036373.1; ENSUAMG00000027564.1.
DR   GeneTree; ENSGT00940000160022; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR008521; Mg_trans_NIPA.
DR   PANTHER; PTHR12570:SF13; MAGNESIUM TRANSPORTER NIPA3; 1.
DR   PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR   Pfam; PF05653; Mg_trans_NIPA; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..175
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019039148"
FT   TRANSMEM        28..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        94..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        127..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   175 AA;  19590 MW;  3F3B3621A7E36A7A CRC64;
     MLFFITVISL VLILIVAPKK GQTNILVYIS ICSLIGAFSV SSVKGLGIAI KELLEWKPVY
     KHPLVFVLLA VLVLSVTTQI NYLNKALDTF NTSLVTPIYY VFFTSMVVTC SAILFQEWYG
     MKAGDIIGTL SGFFTIINGI FLLHAFNFKL LKLRREVTDA PPPHFYNFLL SKLDS
//