ID   A0A452STX0_URSAM        Unreviewed;       268 AA.
AC   A0A452STX0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=exodeoxyribonuclease III {ECO:0000256|ARBA:ARBA00012115};
DE            EC=3.1.11.2 {ECO:0000256|ARBA:ARBA00012115};
GN   Name=TREX2 {ECO:0000313|Ensembl:ENSUAMP00000036347.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036347.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000036347.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.11.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000493};
CC   -!- SIMILARITY: Belongs to the exonuclease superfamily. TREX family.
CC       {ECO:0000256|ARBA:ARBA00025769}.
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DR   AlphaFoldDB; A0A452STX0; -.
DR   STRING; 9643.ENSUAMP00000036347; -.
DR   Ensembl; ENSUAMT00000040446.1; ENSUAMP00000036347.1; ENSUAMG00000027544.1.
DR   GeneTree; ENSGT00390000012715; -.
DR   OMA; HIEPMYV; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:Ensembl.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   CDD; cd06136; TREX1_2; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR040393; TREX1/2.
DR   PANTHER; PTHR13058; THREE PRIME REPAIR EXONUCLEASE 1, 2; 1.
DR   PANTHER; PTHR13058:SF24; THREE PRIME REPAIR EXONUCLEASE 2; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          41..242
FT                   /note="Exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00479"
SQ   SEQUENCE   268 AA;  29395 MW;  43872CB3182A6B25 CRC64;
     GWACGYPLPR AGMVCASCPD SFRLCCPCEH ITMSEAPRAE TFVFLDLEAT GLPSIDPEVA
     ELSLFAVHRS SLENPDRDES GAPVLPRVLD KLTLCMSPER PFTAKASEIT GLSSDSLARC
     RKAGFDNAVV RTLQAFLSRQ EGPICLVAHN GFDYDFPLLC TELRRLGAHL PLDTICLDTL
     PALRSLDRTH SHGTRARGCK GYSLGSLFRR YFQAEPSAAH SAEGDVHTLL MVFLHRAAEL
     LGWADEQARS WAHIEPMYVP PDGPSLEV
//