ID A0A452STX0_URSAM Unreviewed; 268 AA.
AC A0A452STX0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=exodeoxyribonuclease III {ECO:0000256|ARBA:ARBA00012115};
DE EC=3.1.11.2 {ECO:0000256|ARBA:ARBA00012115};
GN Name=TREX2 {ECO:0000313|Ensembl:ENSUAMP00000036347.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036347.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000036347.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.11.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000493};
CC -!- SIMILARITY: Belongs to the exonuclease superfamily. TREX family.
CC {ECO:0000256|ARBA:ARBA00025769}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452STX0; -.
DR STRING; 9643.ENSUAMP00000036347; -.
DR Ensembl; ENSUAMT00000040446.1; ENSUAMP00000036347.1; ENSUAMG00000027544.1.
DR GeneTree; ENSGT00390000012715; -.
DR OMA; HIEPMYV; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR CDD; cd06136; TREX1_2; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR040393; TREX1/2.
DR PANTHER; PTHR13058; THREE PRIME REPAIR EXONUCLEASE 1, 2; 1.
DR PANTHER; PTHR13058:SF24; THREE PRIME REPAIR EXONUCLEASE 2; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 41..242
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
SQ SEQUENCE 268 AA; 29395 MW; 43872CB3182A6B25 CRC64;
GWACGYPLPR AGMVCASCPD SFRLCCPCEH ITMSEAPRAE TFVFLDLEAT GLPSIDPEVA
ELSLFAVHRS SLENPDRDES GAPVLPRVLD KLTLCMSPER PFTAKASEIT GLSSDSLARC
RKAGFDNAVV RTLQAFLSRQ EGPICLVAHN GFDYDFPLLC TELRRLGAHL PLDTICLDTL
PALRSLDRTH SHGTRARGCK GYSLGSLFRR YFQAEPSAAH SAEGDVHTLL MVFLHRAAEL
LGWADEQARS WAHIEPMYVP PDGPSLEV
//