ID A0A452SUE2_URSAM Unreviewed; 1001 AA.
AC A0A452SUE2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=SEC24 homolog D, COPII coat complex component {ECO:0000313|Ensembl:ENSUAMP00000036493.1};
GN Name=SEC24D {ECO:0000313|Ensembl:ENSUAMP00000036493.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036493.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000036493.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR AlphaFoldDB; A0A452SUE2; -.
DR Ensembl; ENSUAMT00000040604.1; ENSUAMP00000036493.1; ENSUAMG00000027315.1.
DR GeneTree; ENSGT00950000182924; -.
DR OMA; QNGAHAS; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 2.
DR Gene3D; 3.40.20.10; Severin; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803:SF6; PROTEIN TRANSPORT PROTEIN SEC24D; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 352..390
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 429..672
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 678..762
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 774..873
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 892..945
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..182
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 109182 MW; B76633DCDFE8DEC3 CRC64;
MSQQGYVATP PYSQSQPGIG LSPPHYGHYG DPSHAGSPPG MMKPAGPLGA AAPGGMLPQG
PSPPGPHQFG QNGAHAQGHP PQRFPGPPPV NSAASSYAPY SPSTPSSYPS PASTSVIAQL
GHQLSAMHIN SYGSGMAPPG QGPPGPPSAP LFQGPPQPPQ PSIMQPGSQV LPPPPTTALN
GPGASPLPPS THRQDGLPGP APLNAQYQPP PPPGQTLGTG YSPQQANYGP QMAGGQLSYP
GGFPGGPAQM AGPPQLQKKL DPDSIPSPVS RGQVYATNTR GQVPPLVTTD CVIQDQGNAS
PRYIRCTTYC FPCTSDMAKQ AQIPLAAVIK PFATIPSNET PLFLVNHGEN GPVRCNRCKA
YMCPFMQFIE GGRRYQCGFC NCVNDVPPFY FQHLDHIGRR LDHYEKPELS LGSYEYVATL
DYCRKNKPPN PPAFIFMIDV SYSNIKNGLV KLICEELKTV LEKLPKEEQE DTSAIRVGFI
TYNKVLHFFN VKSNLAQPQM MVVTDVGEVF VPLLDGFLVN YQESQSVIHN LLDQIPEMFA
DSNENETVFA PVIQAGMEAL QAADCPGKLF IFHSSLPTAE APGKLKNRDD KKLINTDKEK
ILFQPQTNVY DSLAKDCVAH GCCVTLFLFP SQYVDVASLG LVPQLTGGTL YKYNNFQMHM
DSQQFLNDLR NDIEKKIGFD AIMRVRTSTG FRATDFFGGI FMNNTTDVEM AAIDCDKAVT
VEFKHDDKLG EDSGALIQCA VLYTTVGGQR RLRIHNLSLN CSSQLADLYK SCETDALINF
FAKSAFKAVL HQPLKVIREI LVNQTAHMLA CYRKNCASPS AASQLILPDS MKVLPVYMNC
LLKNCVLLSR PEISTDERAY QRQLVMTMGV ADSQLFFYPQ LLPIHTLDVK STTLPAAIRC
SESRLSEEGI FLLANGLNMF LWLGVSSPPE LIQGIFNVPS FAHVSTDMVS IFFFHTKLIK
QREQPEMVFR QFLVEDKGLY GGSSYVDFLC CVHKEICQLL N
//
