ID A0A452SUI9_URSAM Unreviewed; 752 AA.
AC A0A452SUI9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=MutL homolog 1 {ECO:0000313|Ensembl:ENSUAMP00000036464.1};
GN Name=MLH1 {ECO:0000313|Ensembl:ENSUAMP00000036464.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036464.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000036464.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR AlphaFoldDB; A0A452SUI9; -.
DR Ensembl; ENSUAMT00000040573.1; ENSUAMP00000036464.1; ENSUAMG00000027612.1.
DR GeneTree; ENSGT00800000124177; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 224..330
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 397..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 83883 MW; F875C283BCB40161 CRC64;
LGSSGAKMSL VAGVIRRLDE TVVNRIAAGE VIQRPANAIK EMIENCLDAK STSIQVVVKE
GGLKLIQIQD NGTGIRKEDL DIVCERFTTS KLQSFEDLAS ISTYGFRGEA LASISHVAHV
TITTKTADAK CAYRYANYSD GKLKAPPKPC AGNQGTQITV EDLFYNISTR RKALKNPSEE
YGKILEVVGR YSIHNSGISF SVKKQGETVA DVRTLPNATT VDNIRSIFGN AVSRELIEVG
CEDKTLAFKM NGYISNANYS VKKCIFLLFI NRKEFYGMVE KFRIHRFDYT LDISPQNVDV
NVHPTKHEVH FLHEDSILER VQQHIESKLL GSNSSRMYFT QTLLPGLAGS SVEVVKSTTG
VTPSSTGSGD KVYAHQMVRT DSREQKLDAF LQPMSKALSS QPQAIVPEDR TDASSGGAGQ
QDEEMLELPE PAQVAATNQG TEVDVTEGTS ETSEKRGPSS SPGNPRKRPR ESSDVEMVED
DSRKEMTAAC TPRRRIINLT SVLSLQEEIN ERGHETLREM LHNHSFVGCV NPQWALAQHQ
TKLYLLNTTK LSEELFYQIL IYDFANFGVL RLSEPAPLFD LAMLALDSPE SGWTEEDGPK
EGLAEYIVEF LKKKAEMLAD YFSLEIDEEG NLIGLPLLID NYVPPLEGLP IFILRLATEV
NWDEEKECFE SLSKECAIFY SIRKQYISEE STLSGQQSEV SGSSAKPWKW TVEHIVYKAF
RSHLLPPKHF TEDGNILQLA NLPDLYKVFE RC
//
