ID A0A452SUY3_URSAM Unreviewed; 1065 AA.
AC A0A452SUY3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Solute carrier family 12 member 5 {ECO:0000313|Ensembl:ENSUAMP00000036635.1};
GN Name=SLC12A5 {ECO:0000313|Ensembl:ENSUAMP00000036635.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036635.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000036635.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A452SUY3; -.
DR Ensembl; ENSUAMT00000040777.1; ENSUAMP00000036635.1; ENSUAMG00000022279.1.
DR GeneTree; ENSGT00940000160827; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 106..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..283
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 406..683
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 697..815
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 828..902
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 998..1065
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 117953 MW; 6003EBE2857F250B CRC64;
GHTAGCAGRG MTTSWYQTPD SSAFPGDGNP KESSPFINST DTEKGREYDG KNMALFEEEM
DTSPMVSSLL SGLANYTNLP QGSREHEEAE NNEGGKKKPK SAPRMGTFMG VYLPCLQNIF
GVILFLRLTW VVGIAGIMEA FCMVFICCSC TMLTAISMSA IATNGVVPAG GSYYMISRSL
GPEFGGAVGL CFYLGTTFAG AMYILGTIEI LLAYLFPAMA IFKAEDASGE AAAMLNNMRV
YGTCVLTCMA TVVFVGVKYV NKFALVFLGC VILSILAIYA GVIKSAFDPP NFPICLLGNR
TLSRHGFDVC AKLAWEGNET VTTRLWGLFC SSRFLNATCD EYFTRNNVTE IQGIPGAASG
LIKENLWSSY LTKGVIVERR GMPSVGLAES TPVDMDHPYV FSDMTSYFTL LVGIYFPSVT
GIMAGSNRSG DLRDAQKSIP TGTILAIATT SAVYISSVVL FGACIEGVVL RDKFGEAVNG
NLVVGTLAWP SPWVIVIGSF FSTCGAGLQS LTGAPRLLQA ISRDGIVPFL QVFGHGKANG
EPTWALLLTA CICEIGILIA SLDEVAPILS MFFLMCYMFV NLACAVQTLL RTPNWRPRFR
YYHWTLSFLG MSLCLALMFI CSWYYALVAM LIAGLIYKYI EYRGAEKEWG DGIRGLSLSA
ARYALLRLEE GPPHTKNWRP QLLVLVRVDQ DQNVVHPQLL SLTSQLKAGK GLTIVGSVLE
GTFLDNHPQA QRAEESIRRL MEAEKVKGFC QVVISSNLRD GVSHLIQSGG LGGLQHNTVL
VGWPRNWRQK EDHQTWRNFI ELVRETTAGH LALLVTKNVS MFPGNPERFS EGSIDVWWIV
HDGGMLMLLP FLLRHHKVWR KCKMRIFTVA QMDDNSIQMK KDLTTFLYHL RITAEVEVVE
MHESDISAYT YEKTLVMEQR SQILKQMHLT KNEREREVRL PWLGSQLWVC TVGRGEGEAD
PEKVHLTWTK DNSRAFLPSA SPFTPPPPPL RNQSNVRRMH TAVRLNEVIV KKSRDAKLVL
LNMPGPPRNR NGDENYMEFL EVLTEHLDRV MLVRGGGREV ITIYS
//
