ID A0A452SV29_URSAM Unreviewed; 687 AA.
AC A0A452SV29;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Eomesodermin {ECO:0000313|Ensembl:ENSUAMP00000036778.1};
GN Name=EOMES {ECO:0000313|Ensembl:ENSUAMP00000036778.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036778.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000036778.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR AlphaFoldDB; A0A452SV29; -.
DR STRING; 9643.ENSUAMP00000036778; -.
DR Ensembl; ENSUAMT00000040939.1; ENSUAMP00000036778.1; ENSUAMG00000027862.1.
DR GeneTree; ENSGT00940000158728; -.
DR OMA; TMKCEDM; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0002302; P:CD8-positive, alpha-beta T cell differentiation involved in immune response; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032385; T-box_assoc.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF13; EOMESODERMIN HOMOLOG; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF16176; T-box_assoc; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 253..438
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 25..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 73046 MW; E5C00774C0A5A44B CRC64;
MQLGEQLLVS SVNLPGAHFY PLESARGGGS GSAGHLPGAA PSPQRLDLDK APKKFPGSLS
CETGSGEPAA ASAGAPAAML SDADAGDAFA SAAAVAKPGP PDGRKGSPCG EEELPSAAAA
AAARYYLQSP GPQGSELAAP CSLFPYQAAA GAPHGSVYPA PNGARYPYGS MLPPGGFPAA
MCPPGRAQFG PGAGASSGAG AGGGGGAGGP GAYQYSQGAP LYGPYPGAAA AGSCGGLGGL
GVPGSGFRAH VYLCNRPLWL KFHRHQTEMI ITKQGRRMFP FLSFNINGLN PTAHYNVFVE
VVLADPNHWR FQGGKWVTCG KADNNMQGNK MYVHPESPNT GSHWMRQEIS FGKLKLTNNK
GANNNNTQMI VLQSLHKYQP RLHIVEVTEE GVEDLNEPSK TQTFTFSETQ FIAVTAYQNT
DITQLKIDHN PFAKGFRDNY DSMYTASEND RLTPSPTDSP RSHQIVPGGR YGVQSFFPEP
FVNTLPQARY YNGERTVPQT NGLLSPQQSE EVANPPQRWL VTPVQQPGTN KLDIGSYESE
YTSSTLLPYG IKSLPLQTSH ALGYYPDPTF PAMAGWGGRG SYQRKMAAGL PWTSRTSPPV
FSEDQLSKEK VKEEISSSWI ETPPSIKSLD SNDSGVYTSA CKRRRLSPST SSNENSPSIK
CEDINAEEYS KDTSKGMGGY YAFYTTP
//
