ID A0A452SVU3_URSAM Unreviewed; 1627 AA.
AC A0A452SVU3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 {ECO:0000313|Ensembl:ENSUAMP00000036986.1};
GN Name=PREX1 {ECO:0000313|Ensembl:ENSUAMP00000036986.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036986.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000036986.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSUAMT00000041166.1; ENSUAMP00000036986.1; ENSUAMG00000027977.1.
DR GeneTree; ENSGT00940000159925; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 65..230
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 261..382
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 411..486
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 519..587
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 615..662
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1627 AA; 182959 MW; F2A7FD396CCC8C8C CRC64;
LLKKNSRTPG GTGPATFPPD HTWKGEAATP PTFDGTCLPA PRSPQHPPFI GICHLTEDRD
DFSAFLHRIR QNVADSVEKG LTEENVKVLF SNIEDILEVH KDFLAALEYC LHPEPQSQHE
LGNVFLKFKD KFCVYEEYCS NHEKALRLLV ELNKIPTVRA FLLSCMLLGG RKTTDIPLEG
YLLSPIQRIC KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET KRQMEKLEAL
EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY CKRKSRVTGS
KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS NGYTVTNGWK IHNTAKNKWF
VCMAKTAEEK QKWLDAIIRE REQRESLKLG MERDAYVMIA EKGEKLYHMM MNKKVNLIKD
RRRKLSTVPK CFLGNEFVAW LLEIGEISKT EEGVNLGQAL LENGIIHHVS DKHQFKNEQV
MYRFRYDDGT YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK SVLPGSKLVD
WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFKDES QYFRFHADEE MEGTSCKNKQ
LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS VQRGSLAEMA GLQVGRKIYS
INEDLVFLRP FAEVESVLNQ SFCSRRPLRL LVATKAKEII KVPDHPEALC FQIRGAAPPY
VYAVGRGSEA AAAGLCAGQC ILKVNGNNVV SEGAPEVLEH FQAFRNHQEE ALGLYQWVYH
THEDAQEARA SQEAPGEDPQ SDSAFPLLSL GPQLSLHEDS PVVTLTVDNV HLEHGVVYEY
VSTAGVKCHV LEKIVEPRGC FGLAAKILKA FAADDSVFVQ NCGRLMALNN NIKTMSHYEF
RNICDTKLES IGQRIACYQE FAAQLKSRVS PPFKQASLEP HPLCGLDFCP TNCHVNLMEV
SYPKTTPSVG RSFSIRFGRK PSLIGLDPEQ GHLNPMSYTQ HCITTMAAPS WKCLPAVDGD
PQHQGLNDSG FGSASETAGQ EDRGLSFLLK QEDREIQGAY RQLFTKLDVA LKEMKQYVSQ
INRLLSTITE PTSGGSCDPP LAEEASSPPL ANEDTEMDRA DHGGIKKVCF KVSEEDQEDS
GHDTMSYRDS YSECNSNRDS VLSYTSVRSN SSYLGSDEMG SGDELPCDMR IPSDKQDKLH
GCLEHLFNQV DSIHALLKGP VMSRAFEETK HFPMDHSLQE FKQKEECTIR GRSMIQISIQ
EDPWNLPNSI KTLVDNIQRY VEDGKNQLLL ALLKCTDPEL QLRRDTIFCQ ALVAAVCTFS
EQLLAALSYR YNNNGEYEES SRDASRKWLE QVAATGVLLH CQSLLSPAAL KEERTMLEDI
WVTLSELDNV TFSFKQLDEN YVANTNVLYH IEGSRQALKV VFYLDSYHFS KLPSRLEGGA
SLRLHTVLFT KALEHAEGPP PPGSQAVEDL QQEINAQSLE KVQQYYRKLR AFYLERSNLP
TDASTTAVKI DQLIRPINAL DELCRLMKSF VHPKPGASGS LGAGLIPISS ELCYRLGACQ
IAMCGTGMQR STLSVSLEQA AILARSHGLL PKCIMQATDI MRKQGPRVEI LAKNLRIKDQ
MPQGAPR
//