GenomeNet

Database: UniProt
Entry: A0A452SVU3_URSAM
LinkDB: A0A452SVU3_URSAM
Original site: A0A452SVU3_URSAM 
ID   A0A452SVU3_URSAM        Unreviewed;      1627 AA.
AC   A0A452SVU3;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 {ECO:0000313|Ensembl:ENSUAMP00000036986.1};
GN   Name=PREX1 {ECO:0000313|Ensembl:ENSUAMP00000036986.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000036986.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000036986.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSUAMT00000041166.1; ENSUAMP00000036986.1; ENSUAMG00000027977.1.
DR   GeneTree; ENSGT00940000159925; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04440; DEP_2_P-Rex; 1.
DR   CDD; cd00136; PDZ; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd01224; PH_Collybistin_ASEF; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR   Pfam; PF00610; DEP; 2.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00049; DEP; 2.
DR   SMART; SM00228; PDZ; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS50186; DEP; 2.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          65..230
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          261..382
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          411..486
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          519..587
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          615..662
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1090..1117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1133..1152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1627 AA;  182959 MW;  F2A7FD396CCC8C8C CRC64;
     LLKKNSRTPG GTGPATFPPD HTWKGEAATP PTFDGTCLPA PRSPQHPPFI GICHLTEDRD
     DFSAFLHRIR QNVADSVEKG LTEENVKVLF SNIEDILEVH KDFLAALEYC LHPEPQSQHE
     LGNVFLKFKD KFCVYEEYCS NHEKALRLLV ELNKIPTVRA FLLSCMLLGG RKTTDIPLEG
     YLLSPIQRIC KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET KRQMEKLEAL
     EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY CKRKSRVTGS
     KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS NGYTVTNGWK IHNTAKNKWF
     VCMAKTAEEK QKWLDAIIRE REQRESLKLG MERDAYVMIA EKGEKLYHMM MNKKVNLIKD
     RRRKLSTVPK CFLGNEFVAW LLEIGEISKT EEGVNLGQAL LENGIIHHVS DKHQFKNEQV
     MYRFRYDDGT YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK SVLPGSKLVD
     WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFKDES QYFRFHADEE MEGTSCKNKQ
     LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS VQRGSLAEMA GLQVGRKIYS
     INEDLVFLRP FAEVESVLNQ SFCSRRPLRL LVATKAKEII KVPDHPEALC FQIRGAAPPY
     VYAVGRGSEA AAAGLCAGQC ILKVNGNNVV SEGAPEVLEH FQAFRNHQEE ALGLYQWVYH
     THEDAQEARA SQEAPGEDPQ SDSAFPLLSL GPQLSLHEDS PVVTLTVDNV HLEHGVVYEY
     VSTAGVKCHV LEKIVEPRGC FGLAAKILKA FAADDSVFVQ NCGRLMALNN NIKTMSHYEF
     RNICDTKLES IGQRIACYQE FAAQLKSRVS PPFKQASLEP HPLCGLDFCP TNCHVNLMEV
     SYPKTTPSVG RSFSIRFGRK PSLIGLDPEQ GHLNPMSYTQ HCITTMAAPS WKCLPAVDGD
     PQHQGLNDSG FGSASETAGQ EDRGLSFLLK QEDREIQGAY RQLFTKLDVA LKEMKQYVSQ
     INRLLSTITE PTSGGSCDPP LAEEASSPPL ANEDTEMDRA DHGGIKKVCF KVSEEDQEDS
     GHDTMSYRDS YSECNSNRDS VLSYTSVRSN SSYLGSDEMG SGDELPCDMR IPSDKQDKLH
     GCLEHLFNQV DSIHALLKGP VMSRAFEETK HFPMDHSLQE FKQKEECTIR GRSMIQISIQ
     EDPWNLPNSI KTLVDNIQRY VEDGKNQLLL ALLKCTDPEL QLRRDTIFCQ ALVAAVCTFS
     EQLLAALSYR YNNNGEYEES SRDASRKWLE QVAATGVLLH CQSLLSPAAL KEERTMLEDI
     WVTLSELDNV TFSFKQLDEN YVANTNVLYH IEGSRQALKV VFYLDSYHFS KLPSRLEGGA
     SLRLHTVLFT KALEHAEGPP PPGSQAVEDL QQEINAQSLE KVQQYYRKLR AFYLERSNLP
     TDASTTAVKI DQLIRPINAL DELCRLMKSF VHPKPGASGS LGAGLIPISS ELCYRLGACQ
     IAMCGTGMQR STLSVSLEQA AILARSHGLL PKCIMQATDI MRKQGPRVEI LAKNLRIKDQ
     MPQGAPR
//
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