ID A0A452SWD6_URSAM Unreviewed; 1107 AA.
AC A0A452SWD6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Lysine demethylase 5D {ECO:0000313|Ensembl:ENSUAMP00000037315.1};
GN Name=KDM5D {ECO:0000313|Ensembl:ENSUAMP00000037315.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000037315.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000037315.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452SWD6; -.
DR Ensembl; ENSUAMT00000041540.1; ENSUAMP00000037315.1; ENSUAMG00000028246.1.
DR GeneTree; ENSGT00940000161236; -.
DR OMA; SAVNCKC; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR048615; KDM5_C-hel.
DR InterPro; IPR013637; Lys_sp_deMease-like_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR004198; Znf_C5HC2.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF43; LYSINE-SPECIFIC DEMETHYLASE 5C; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF21323; KDM5_C-hel; 1.
DR Pfam; PF08429; PLU-1; 1.
DR Pfam; PF02928; zf-C5HC2; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 20..186
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 866..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 124897 MW; 46E279857943E3BA CRC64;
RVMPQSQNLS SLNLKHYSWE YATSGWNLNV MPVLDQSVLC HINADISGMK VPWLYVGMVF
SAFCWHIEDH WSYSINYLHW GEPKTWYGVP SLAAEQLEEV MKRLTPELFD SQPDLLHQLV
TLMNPNTLMS HGVPVVRTNQ CAGEFVITFP RAYHSGFNQG YNFAEAVNFC TADWLPAGRQ
CIEHYRRLRR YCVFSHEELI CKMAAFPEKL DLNLAVAVHK EMFIMVQEER RLRKAVLEKG
ITEAEREAFE LLPDDERQCM KCKTTCFLSA LACYDCPDGL VCLFHINDLC KCSSSRQYLR
YRYTLDELPA MLHKLKIRAE SFDTWANKVR VALDVEDGRK RSFEELRALE SEARERRFPN
SELLQRLRNC LNEAEACVSQ VLGLVSGQDA RIETPQPTVT ELRVLLEQMG SLPCAMHQIG
DVKDVLEQVE AYQIEAREAL ASLPPSVGLL QSLLEKGQQL GIEVPEAYEL QQQVEQAQWL
DEVKQALAPS AQRGSLVIMQ ELLVTGAKIA SSPSVDKARA ELQELLTIAE RWEEKAHFCL
EARQKHPPAI LEAIIREAEN IPVYLPNIQA LKDALAKAQA WIADVDEIQN GDHYPCLDDL
EGLVAIGRDL PVGLEELRQL EVQVLTAHSW REKASKTFLK KNSCYTLLEV LCPCADAGSD
TSKRSRWIEK ELGFYRSDTE LLGLSAQDLR DPGSVIVAFK DGEQKEKEGI LQLRRMNSSK
PSPLASSRTA SSATSICVCG QVPAGVGALQ CDLCQDWFHG QCVSVPRLLS SSRPSSTSSP
LLAWWEWDTK FLCPLCMRSR RPRLETILSL LVALQRLPVR LPEGEALQCL TERAIVWQGR
ARQALASEDV TALLGQLAEL RHQLQEEPTN CRLEESPTYP ATPDSDPHRE GSGKDMPKQA
PGLLSNVDSM TSHEKVAPVQ GSGKTCLEVL SSLLPQLTGP VLNLPEATRA PLEELMLEGD
LLEVTLDENH SIWQLLQAGQ PPDVERIRTL LELEKPEHKG NRTRGRALEK RRRRQQQKID
LGRKSKDLVQ EELQSKKARN SGIKPKEGQE EFEDETDSEN IFLTSTDHRP ILKGNQNTFH
QNNSGSVVSF PSLTPLLHHS CPQQEEL
//
