ID   A0A452SWI2_URSAM        Unreviewed;      2137 AA.
AC   A0A452SWI2;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Dynein axonemal heavy chain 5 {ECO:0008006|Google:ProtNLM};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000037364.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000037364.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   STRING; 9643.ENSUAMP00000037364; -.
DR   Ensembl; ENSUAMT00000041595.1; ENSUAMP00000037364.1; ENSUAMG00000028302.1.
DR   GeneTree; ENSGT00940000155533; -.
DR   OMA; CELLEAY; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005929; C:cilium; IEA:UniProt.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46961:SF14; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 2.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          314..394
FT                   /note="Dynein heavy chain 3 AAA+ lid"
FT                   /evidence="ECO:0000259|Pfam:PF17857"
FT   DOMAIN          470..531
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          550..700
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          716..1059
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   DOMAIN          1089..1309
FT                   /note="Dynein heavy chain ATP-binding dynein motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12781"
FT   DOMAIN          1555..1663
FT                   /note="Dynein heavy chain region D6 P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF03028"
FT   DOMAIN          1695..1834
FT                   /note="Dynein heavy chain AAA lid"
FT                   /evidence="ECO:0000259|Pfam:PF18198"
FT   DOMAIN          1843..2134
FT                   /note="Dynein heavy chain C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18199"
FT   COILED          724..758
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          951..999
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1250..1277
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2137 AA;  245547 MW;  EE5BA01EC613C8AE CRC64;
     SILKKKKEIE KNLQIRCFSH LYNIIRNLHK KLQSVKCIFT KYVCLSVYLS IPQVYLMCIH
     IYTYIYIHTH THNIYISSFF GEWRHWNTCT EEYVYPPDVT PEYGSILVPN VDNVRTDFLI
     KTIAKQGKAV LLIGEQGTAK TVIIKGFMSK YDSESHMIKS LNFSSATTPL MFQRTIESYV
     DKRMGTTYGP PAGKKMTVFI DDVNMPIINE WGDQVTNEIV RQLMEQNGFY NLEKPGEFTS
     IVDIQFLAAM IHPGGGRNDI PQRLKRQFCI FNCTLPSDAS MDKIFGVIGR GYYCVQRGFS
     EEVRDSVMRL VPLTRRLWQM TKNKMLPTPA KFHYVFNLRD LSRIWQGMLN TTSEVIKEPD
     ELLRLWKHEC KRVIADRFTV SSDVTWFNKA LVGLVEEEFG EEKKLLVDCG TDTYFVDFLR
     DAPEATGETS EEADAEMPKI YEPIESFDHL KERLNMFLQL YNESIRGAGM DLVFFKDAMV
     HLVKISRVIG TPRGNALLVG VGGSGKQSLT RLASFIAGYA SFQITLTRPL ELKNAFFLYV
     RNQSFFFLNV SNLFARDEID EINSDLLSVM KKEYPRHPPT NENLHDYFMS RVRQNLHIVL
     CFSPVGEKFR NRALKFPALI SGCTIDWFSR WPKDALVAVS EHFLSSYDID CGLETKRQVV
     QCMGSFQDGV AEKCVDYFQR FRRSTHVTPK SYLSFIQGYK CTYREKHVEV QTLANRMNTG
     LGKLKEASES IAALSKELQV KEKELQVAND KADTVLKEVT MKAQAAEKVK AEVQKVKDKA
     QAIVDGISKD KAIAEEKLER AKPALEEAEA ALQTIKPSDI ATVRTLGRPP HLIMRIMDCV
     LLLFQRKVNA VKIDLDKSCT IPSWQESLKL MTAGNFLQNL QQFPKDTINE EVIEFLNPYF
     EMADYNIETA KRVCGNVAGL CSWTKAMASF FSINREVLPL KANLVVQENR YILAMQDLQK
     AQAELDDKQR ELDVVQTEYE QAMTEKQTLL EDAERCRRKM QTASTLIGGL AGEKERWTEQ
     SKEFAAQTKR LVGDVLLATA FLSYSGPFNQ EFRNLLLNDW QKEMKAREIP FGDNLDLNEM
     LIDAPTVSEW NLQGLPNDDL SIQNGIIVTK ASRYPLLIDP QTQGKMWIKN KESQNELQIT
     SLNHKYFRNH LEDSLSLGRP LLIEDVGEEL DPALDNVLER NFIKTGSTFK VKVGDKEVDV
     MDGFRLYVTT KLPNPAYTPE ISARTSIIDF TVTMKGLEDQ LLGRVILTEK RELEKERTHL
     MEDVTANKRK MKELEDNLLY RLTSTQGSLV EDEGLIVVLS NTKKTAEEVT QKLEISAETE
     IQINSAREEY RPVATRGSIL YFLITEMRLV NEMYQTSLRQ FLALFDLSLA RSVKSPITSK
     RIANIIEHMT YEVYKYAARG LYEEHKFLFT LLLTLKIDIQ RNRIKHEEFL TLIKGGASLD
     LKACPPKPSK WILDMTWLNL VELSKLRQFS DVLDQISRNE KMWKIWFDKE NPEEEPLPNA
     YDKSLDCFRR LLLIRSWCPD RTIAQARKYI MDSMGERYAE GIILDLEKTW EESDPRTPLI
     CLLSMGSDPT DSIIALGKRL KIETRYVSMG QGQEVHARKL LQQTMANGGW ALLQNCHLGL
     DFMDELMDII IETETVHDAF RLWMTTEVHK HFPITLLQMA IKFANEPPQG LRAGLKRTYG
     GVSQDLLDVS TAAQWKPMLY AVAFLHSTVQ ERRKFGPLGW NIPYEFNQAD FNATVQFIQN
     HLDDMDVKKG VSWTTIRYMV GEIQYGGRVT DDYDKRLLNA FAKVWFSENM FGSDFSFYQG
     YNIPKCNTVD NYLQYIQSLP TYDSPEVFGL HPNADITYQS KLAKDVLDTI LSIQPKDSAG
     GADETREAVV ARLADDMLEK LPPDYGPFEV KERLQKMGPF QPMNIFLRQE IDRMQRLLTL
     VRSTLTELKL AIDGTTIMSE DLGDALNCMF DARIPARWKK ASWVSSTLGF WFTELLERNC
     QFTSWVFNGR PCCFWMTGFF NPQGFLTAMR QEITRANKGW ALDNMVLCNE VTKWMKDDIS
     APPTEGVYVY GLYLEGAGWD KRNMKLIESK PKVLFELMPV IRIYAENNSK DPQFYSCPIY
     KKPVRTDLNY IAAVDLRTAQ VPEHWVLRGV ALLCDVK
//