ID A0A452YWY5_AEGTS Unreviewed; 864 AA.
AC A0A452YWY5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET1Gv20558400.1, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET1Gv20558400.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR AlphaFoldDB; A0A452YWY5; -.
DR EnsemblPlants; AET1Gv20558400.1; AET1Gv20558400.1; AET1Gv20558400.
DR Gramene; AET1Gv20558400.1; AET1Gv20558400.1; AET1Gv20558400.
DR OMA; YTEILYP; -.
DR OrthoDB; 20951at2759; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000015105; Chromosome 1D.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF0; AMP DEAMINASE; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015105}.
FT REGION 47..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 97539 MW; D1928429C73DB9D9 CRC64;
MDSASASYKL QLACAALVGA SAAAASAYYL HCRAVAQLSG DIVRNSAAAA KGDRERRRPR
EAAGRNPPPP RRAAAGSSSL PDLSSIYAAG GVARGYPVEE YDDGDGEGVG AYVDEALLAA
AAYMQIPTGL PRLQVGPEGN KQIVRSGSSR RVGLIRPNSP KSPFASASTL ESVEGSDEDA
AMKVNGKLDN GHASTNGNLE GEHKGNSVVE NGAGTPLDAK NMTRSHSISN DLHAVQPDPV
AADILRKEPQ QESFIKLLTA PHEIPSPDEI EVYKILQKCL ELRDCYLFRE EVAPWEKEVI
NDPCTPKPNP NPFTFVPESK SEHVFQMVDG VVQVYADKDR TERIYPVADA TTFFTDLHYV
LRMTAAGNTR TVCHNRLNLL EHKFKFHLML NADREFLAQK TAPHRDFYNV RKVDTHVHHS
ACMNQKHLLR FIKSKLRKEP DEVVIFRDGT YMTLKEVFES LDLTGYDLNV DLLDVHADKS
TFHRFDKFNL KYNPCGQSRL REIFLKQDNL IQGRFLAELT MQVFSDLNAS KYQMAEYRIS
IYGRKQSEWD QLASWIVNNE LYSENVVWLI QIPRLYNVYQ QMGIVTSFQN LLDNIFLPLF
EVTIDPASHP QLHVFLKQVV GLDLVDDESK PERRPTKHMP TPEEWTNVFN PAFSYYAYYC
YANLYTLNKL RESKGMNTIK FRPHAGEAGD VDHLAATFLL CHSISHGINL RKSPVLQYLY
YLGQIGLAMS PLSNNSLFLD YHRNPFPMFF QRGLNVSLST DDPLQIHLTK EPLVEEYSIA
ASLWKLSSCD LCEIARNSVY QSGFSHALKA HWIGKNYYKR GPSGNDIHRT NVPTIRIEFR
DLIWRDEMQL VYLNNVILPD EVDQ
//
