ID A0A452ZIJ8_AEGTS Unreviewed; 1305 AA.
AC A0A452ZIJ8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET1Gv20795900.31, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET1Gv20795900.31}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EnsemblPlants; AET1Gv20795900.15; AET1Gv20795900.15; AET1Gv20795900.
DR EnsemblPlants; AET1Gv20795900.26; AET1Gv20795900.26; AET1Gv20795900.
DR EnsemblPlants; AET1Gv20795900.27; AET1Gv20795900.27; AET1Gv20795900.
DR EnsemblPlants; AET1Gv20795900.31; AET1Gv20795900.31; AET1Gv20795900.
DR EnsemblPlants; AET1Gv20795900.32; AET1Gv20795900.32; AET1Gv20795900.
DR Gramene; AET1Gv20795900.15; AET1Gv20795900.15; AET1Gv20795900.
DR Gramene; AET1Gv20795900.26; AET1Gv20795900.26; AET1Gv20795900.
DR Gramene; AET1Gv20795900.27; AET1Gv20795900.27; AET1Gv20795900.
DR Gramene; AET1Gv20795900.31; AET1Gv20795900.31; AET1Gv20795900.
DR Gramene; AET1Gv20795900.32; AET1Gv20795900.32; AET1Gv20795900.
DR Proteomes; UP000015105; Chromosome 1D.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 188..841
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 949..1261
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 1273..1305
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 142..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 696..730
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1305 AA; 149018 MW; 9E44F0AFDA95D212 CRC64;
MVHSRGINTQ LVEQTLLGMD KYSTVPLEDS DIWQTDGQPY EQWLCTLVSS LISHCDDIIL
RLCRSLVFLK VEAAELLLAS ALVNIAGNMD SNSGICGLIS SKVEKIIFCD SNYMMKSVKL
FLDALNVVRS FYVTERARAS PYNTRASPSP YNTPKDGSRS ARSKSRSPAA TPSSSWRKVY
WLSVDYLVAA RAAQRCSCDF ATLMYVELWC EEQFNKLDLG PPDFSQQESL APHIGLLVEA
FTHINEPDSI YGITLANEVA SQIIRYEHEG NWSSALEYYD LLVRSTPKEN LANFAGTVLT
GPSVSSKAEE NLLNWKMHKG LMRSLQKTGC SHVLDIYSQG LTNQKACLQQ DSEFVDIQYE
AAWRAGNWDF SFFVPYSSQP SSRSRDYCLF NENLHSCLRA LQNGDSEQFQ GKLSHSKMDL
VLALSNASKE STKYIHSTVL KLQMLDHLSM AWELRWKFCP DQAPKSNVGT EEFNLVPAVP
KRNQLELLSK EWNFILCQTE RNLDLFEPFL AFRRGLLKIL GSEEHLIEHL FQSASALRKG
LRFSLAAASL YELKELCCHR DQQTVPSTYF LSKLEEAKLL RAQGQHDMAI GLGKYILKNH
TDERNKSDVY RLVGKWLAET RSSNSRTIIE DYLNHSVALD KKYMSRQCRT HFHLAHYTYN
LFKSYEERLS SNEWQAALRL RKYKTKELDT LLKRLKNSSK AEKSDYGAKI QELQKQLALD
REEAQKIQDD RDEFLSLALE GYQRSLVVGG KYDLQVVFRL VSLWFNLFSR KQVVDSMIKT
TKEVQSYKFI PLVYQIASRL GSSKDAQGST NFQNALASLL KKMAIDHPYH TICQLLALAN
GDRVKDKQRS RSSFVVDMDK KLAAENLLKE LSSFHGALIR QMKQMVEIYI RLAELETRKE
DTNKKISLPR EFRSICQLEL AKVPVVTATI PVDPNCRYEE GTFPHFSGLV DSITIMNGIN
APKVIQCIGS DGNRYRQLAK SGNDDLRQDA VMEQFFSLVN MFLQNHRDTS ERRLRIRTYN
VVPFTPSAGV VEWVNRTVPL GDYLLDSNRI GGAHARYGTG DWTFLQCREH LACEKDKRKA
FFKICDNFRP VMHHFFIERF LQPADWFQSR LAYTRSVAAS SMVGYIVGLG DRHSMNILID
EDTAEVVHID LGVAFEQGLM LKTPERVPFR LTRDIIDGMG VTGTEGVFKR CCEKTLSVMR
ENKEALLTII EVFIHDPLYK WALSPLKALQ RQKETEYNDS CLDDSQEACE GNKDAARAIL
RVKQKLDGYE DGEMRSVEGQ VQQLIQDAVD TDRLCQMFPG WAPWL
//
