ID A0A453ADN1_AEGTS Unreviewed; 330 AA.
AC A0A453ADN1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Nicotianamine synthase {ECO:0000256|RuleBase:RU368095};
DE EC=2.5.1.43 {ECO:0000256|RuleBase:RU368095};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET2Gv20082500.2, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET2Gv20082500.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- FUNCTION: Synthesizes nicotianamine, a polyamine which serves as a
CC sensor for the physiological iron status within the plant, and/or might
CC be involved in the transport of iron. {ECO:0000256|RuleBase:RU368095}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-
CC methyl-5'-thioadenosine; Xref=Rhea:RHEA:16481, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17509, ChEBI:CHEBI:58249, ChEBI:CHEBI:59789; EC=2.5.1.43;
CC Evidence={ECO:0000256|RuleBase:RU368095};
CC -!- SIMILARITY: Belongs to the nicotianamine synthase (NAS)-like family.
CC {ECO:0000256|ARBA:ARBA00007009, ECO:0000256|RuleBase:RU368095}.
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DR AlphaFoldDB; A0A453ADN1; -.
DR SMR; A0A453ADN1; -.
DR EnsemblPlants; AET2Gv20082500.1; AET2Gv20082500.1; AET2Gv20082500.
DR EnsemblPlants; AET2Gv20082500.2; AET2Gv20082500.2; AET2Gv20082500.
DR Gramene; AET2Gv20082500.1; AET2Gv20082500.1; AET2Gv20082500.
DR Gramene; AET2Gv20082500.2; AET2Gv20082500.2; AET2Gv20082500.
DR OMA; LEFTMLT; -.
DR OrthoDB; 2718460at2759; -.
DR Proteomes; UP000015105; Chromosome 2D.
DR GO; GO:0030410; F:nicotianamine synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030418; P:nicotianamine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004298; Nicotian_synth.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR32266:SF29; NICOTIANAMINE SYNTHASE; 1.
DR PANTHER; PTHR32266; NICOTIANAMINE SYNTHASE 3; 1.
DR Pfam; PF03059; NAS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51142; NAS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368095};
KW Transferase {ECO:0000256|RuleBase:RU368095}.
SQ SEQUENCE 330 AA; 35307 MW; 931EAAC129E800F8 CRC64;
MAAQNKEVDA LVQKITGLHA AIAKLPSLSP SPDVDALFTE LVTACVPPSP VDVTKLGPEA
QKMREGLIRL CSEAEGKLEA HYSDMLAAFD NPLDHLGMFP YYNNYINLSK LEYELLARYV
PGGIAPARVA FIGSGPLPFS SFVLAARHLP DTMFDNYDLC GAANDRASKL FRADKDVGAR
MSFHTADVAD LAGELAKYDV VFLAALVGMA AEDKAKVIAH LGAHMADGAA LVVRSAHGAR
GFLYPIVDPQ DIAGGGFEVL AVCHPDDDVV NSVIIAQKSK DVHAIGLRRG HGGQYAYGTV
PVVSPPCRFG EMVPDMAQKR EEFANAEVVF
//
