ID A0A453AR92_AEGTS Unreviewed; 1173 AA.
AC A0A453AR92;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA polymerase zeta catalytic subunit {ECO:0000256|ARBA:ARBA00021589};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET2Gv20233300.23, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET2Gv20233300.23}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR AlphaFoldDB; A0A453AR92; -.
DR EnsemblPlants; AET2Gv20233300.23; AET2Gv20233300.23; AET2Gv20233300.
DR Gramene; AET2Gv20233300.23; AET2Gv20233300.23; AET2Gv20233300.
DR Proteomes; UP000015105; Chromosome 2D.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR CDD; cd05778; DNA_polB_zeta_exo; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 664..861
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 928..1163
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 266..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 128867 MW; 9277031FDCFA0DCB CRC64;
MKNPIIWTSS TVPHALILGD SSSSHFMEGS SSNFRKRHTF MMLEADSRVE GIINEKYKMY
TSLSQTMADT KMVQSLLAIW EELEHLRLLD ETKPADIGRP PRDAVLKSFL HGIKYESALS
ALDPKEEGSH HKDSAVEASE KLERCFKSLT DVIGTITFSQ NDCCENIGSD NSAPRTSQSF
DEHEKHVDSE ALGLLSWMAS SQAGEEPTTD DELVNEVILS PLFSKKSIEF ALESAHLDFD
SASQQECQDI LDTLEPVTGA EELNAQKSYH SSPVLDESTS VTNTIPQIDG SSDEKQKGPQ
EYDQGKITRR KIGTASYSSS KNSSKLASKH GGTELLWGSL PLSTKKRSHG NADGPVKISS
GSAMPTEDPS SYNSKTEKNS CHTTDDTDKE SSGSIGEHGP ACLSVRDLMR RKRRGSFQPE
KLDFGCSGTA ACNMDKTSGI VISGGLEVHD VTSGLPNSET SYSGGEYVHM TFAQKPPTGS
EVSSASIEHP ESAKLGSVDP LPFFNQTAEE NKENGSFQYM GSSEFTPDTL GVPTHFQNDG
SLLYLLTHAF SPPSAAAVGQ WLPQHTYSNS VSDDQEIEHH PTSTPHAEAL PLMANSPVPG
SASEHTTTTF IDTVMMKSDQ PNKENKKLDD WHDFSQISAE DEKHKLTPLS QIGFRDPAST
GGGQQLTILS IEVFAESRAE LRPDPRFDAI NVVSLAVEDD GDNTVEVCVL IRGNNDKSQG
RRNLDGVIGC SVDVFPEERD LLNHLIDALC SIDPDILVGW EIQLGSLGFL AERAAYLGIG
LLKRISRTLP HESKHPPKNL AHESSQVPEA SPADDVIMDV SENDWSHTHA SGVHVGGRIV
LNLWRLMRGE VKLNNYSLEA VADEVLRRKV PLVPNKTLNR WFATGPGRGR HRCIEYVSSR
AMLNLEIINQ LDLVNRTSEL ARVFGIDFFS VLSRGSQFRV ESMLLRLAHT QNYLAISPGN
QQVASQPAME CMPLVMEPES AFYSDPVLVL DFQSLYPSMI IAYNLCYSTC LGKVFPSKSS
VLGVSSYSAD PHTIADLKNQ LILTPNGVLY VQPEVRKGVV PRLLEEILST RIMVKQAMKK
LAPSQKVLQK ILNARQLALK LIANVTYGYT AAGFSGRMPC AELADSIVQC GRRTLETAIS
FVNQHPLWNA RVVYGDTDRY FCAILMIFSL NYT
//
