ID A0A453C7X6_AEGTS Unreviewed; 1239 AA.
AC A0A453C7X6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Multidrug resistance protein {ECO:0008006|Google:ProtNLM};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET2Gv20766600.1, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET2Gv20766600.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A453C7X6; -.
DR STRING; 200361.A0A453C7X6; -.
DR EnsemblPlants; AET2Gv20766600.1; AET2Gv20766600.1; AET2Gv20766600.
DR Gramene; AET2Gv20766600.1; AET2Gv20766600.1; AET2Gv20766600.
DR Proteomes; UP000015105; Chromosome 2D.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24222:SF48; ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24222; ABC TRANSPORTER B FAMILY; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 882..905
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..301
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 336..572
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 659..946
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 990..1227
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1239 AA; 133429 MW; BDEAE96D76479D9D CRC64;
TMGDAAAGKA SFLEMVRYAD AHDLSLMMLG VLGSFGDGMM QPLLMLVLGD IINSYGAAGS
AGSAFSSSAV DKGVCWTRTA ERQASRMRRL YLEAVLRQEV HFFDAAPSSQ STTFGIITTI
SDDADTIQDF LSEKLPMVLA NVTLFFGAMS VCFVFAWRLA LAGLPLTFLF FVPSVVLGKR
MVAAAGESRA AYESAGGIAD QAVSSIRTVA SYNGERHTLE RFRSALARST ALGIKQGLIK
GAVIGSMGAI YAVWSFMSWL ASVLVIHQHA QGGHVFVAAI CIVLAGISIM AALPNLRYFV
DASAAAARMR GMIEKLPPLK EAGKKGATKD VVRGQIVFKD VHFMYPSRPD TRVLNGVNLT
MSEGATIGLV GGSGSGKSTV IALLQRFYRP DSGEILLDGD DIGSLNAEWL RSKIGLVSQE
PVLFATSIRE NILFGNETAS PEQIIDAAKM ANAHEFITKL PNGYDTHVGQ FGTQMSGGQK
QRIAIARALI RDPKILLLDE ATSALDSESE RTVQDALDRA SVGRTTVIVA HRLSTLRKAD
TIAVLDQGRV VEFGTHDELV AMDGGEGGVY AKMVHLQSSS VTRADGPRVA EEEEEKFHSV
EIASPGGELR PSPVPSFRSV EPTVEFSKLA VPVAHAAHPQ KSLHLRLLKM NRPEWKQALL
GCAGAIIFGA VLPLYSYSMG SLPAVYFLTD HDLIRAKTRA YSLIFLAIAI VCIAANIVEH
YNFAVMGERL TERVRDQMLA KILSFEVGWF DEDENSSAAV CARLATQATK VRSLVGDRMC
LLVQAGATAS LGFALALYVS WRLAAVMMAL QPLVIASFYF KKVLMTAGSR KAKKAQVQGS
QLASEAVVNH RTITAFSSQR RMLQLYEAAQ VGPRKDTMTQ SWFSGFCLCL CQFNATASTA
LALWYGGKLM ASRQINTTQL FQVFFILMSM GRVIADAGSL TSDLAQGGDA VQSILDTLDR
EPAIKSGTGD GASESDDDKE KLQKGIKGAI EFRDVHFSYP TRPEVTVLAG LSLEIGAGKT
VALVGPSGSG KSTVIGLIER FYDVRSGSIL IDGRDIRGYG LTHLRSHVAL VSQEPTLFSG
TIRDNIMYGD EQATEEEVRS AAALANAHEF ISGMESGYDT QIGERGAQLS GGQRQRIALA
RAVLKNARIL LLDEATSALD TVSERLVQDA VDRMLQGTRT CVVVAHRLST VQNSDMIAVV
KDGRVAERGT HRDLVALGRA GMYYNLVKLQ HGASPCHSP
//
