ID A0A453CIC4_AEGTS Unreviewed; 617 AA.
AC A0A453CIC4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Protein BREAST CANCER SUSCEPTIBILITY 1-like protein {ECO:0008006|Google:ProtNLM};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET2Gv20857900.1, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET2Gv20857900.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
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DR AlphaFoldDB; A0A453CIC4; -.
DR STRING; 200361.A0A453CIC4; -.
DR EnsemblPlants; AET2Gv20857900.1; AET2Gv20857900.1; AET2Gv20857900.
DR Gramene; AET2Gv20857900.1; AET2Gv20857900.1; AET2Gv20857900.
DR OMA; NQQRESC; -.
DR OrthoDB; 318045at2759; -.
DR Proteomes; UP000015105; Chromosome 2D.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR CDD; cd15571; ePHD; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13763:SF9; BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 24..62
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 237..357
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 410..495
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 516..617
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 107..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 617 AA; 66825 MW; 4AEBAF26AC7F71A2 CRC64;
MEGMRRFVNP LKLNVQKMEL ELTCPVCLKL LSAPTMLPCC HTCCSKCATP QAMNGHSCAI
CKLAYHPQDL RHASQIEALV NIQRSISSTV SSMSLQLGTQ PAIHVAKATS QGTPESGRTS
SHNLVASNLP CNQASGPADE NVGVVQAMDP APGNRTNDVA VEPTVIVQTG PCGSQTPVGS
GDLECDSNDL EGELITSGSP PQSTLKRGPN ITDDSTRGLK RQKSSDQSEK QPSMNAAWKC
EFCHSSEISE CTGPLLHCLD EALVKDDQAW KSNVLHVHEK CAEWAPEAYF EGDMIKKLES
ELARSSKMKC GICGLKGAAL GCLFKSCRKS YHLPCARGVS GCRWDEGEFV MLCPTHSSKR
LPCERSNSKN KKAAQLQQPS SETVLGDSNS PFPMEMNELW TSLCPTSEWV ICGSALSDQD
KEILDQFEYH SGVTTTNNWS SNVTHVLANT NEDGACGRTR KVLLAILAGK WVVNVNWLSA
CLEAKKPVPE EPYEIRSDVH GAIDGPRIGR LRAMQKAPSL FSGLIFYFIG HPLTFKVELD
ELIAAAGGSI LGKADLSSTS LIVYNKEVPK GCNEDAVDEV FSKREAEALD LATTFGCRVV
PHTWVLDSIA SCTLQPI
//
