ID A0A453CJP3_AEGTS Unreviewed; 1086 AA.
AC A0A453CJP3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET2Gv20868700.14, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET2Gv20868700.14}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A453CJP3; -.
DR EnsemblPlants; AET2Gv20868700.14; AET2Gv20868700.14; AET2Gv20868700.
DR Gramene; AET2Gv20868700.14; AET2Gv20868700.14; AET2Gv20868700.
DR Proteomes; UP000015105; Chromosome 2D.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR10492:SF94; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR10492; UNCHARACTERIZED; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105}.
FT DOMAIN 4..185
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT DOMAIN 926..972
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
SQ SEQUENCE 1086 AA; 124873 MW; 3FCCAF544A0AFFEB CRC64;
VRDYYCYKFQ MRRGVFNTML YGKRLFQQYV VDMYIKVESS RLDYIKKHQE QIRADLYQGV
VDSLQAGENR ADEVGKRTIV PSSFIGGRRD RRRRYLDAMA LVQKYGKPNI FLTMTCNPNW
DEIISELEPG QTPRDRPDLI VRVFRAKLED LKIQLFKRHI FGKVATYVYV VEFQKRGLPH
AHFLLIMEGR YKLTCPEQYD CLISAELPDK SKYPELYKMV VKHMMHGPCG VLNPKNVCMQ
KGSCKNYYPR PFNVSTLQGK DSYPIYRRRD DGRRAKVRGQ ELDNRWVVPY NPYLLRRYNC
HINVEVCSSI KAVKYLFKYI YKGHDRASVS IDEVDSDRNI DEIKQYRDSR WVTPPEALWR
IYGFDLSQIF PSVRQLQLHL PNMHMVSFPA GANLDDVLSQ EGASKTMLTE YFEANKKYEL
ARGILYKDFP SYFVWMSGGK YWKRRDERMQ IGRIVSAHPA EGERYYLRVL LNHVTGATSF
QDLRTVNGIV YSTFREAAER RGLIESDNTI NECLDEAKVF HMPSSLRRLF ATILVFCEPS
NVRGLWDRHM EAMTEDYRLT QMCPHAVEQM ALLDIKNMLE SMGKDISSFP LPEIDESYDA
SDNEAREIIE ESTIEVDPEH LGLSSFLNPE QRYAYDEILA TINSGQGGVF FVDGPGGTGK
TYLYKALLAK VRAEGKIAVA TATSGVAASI LPGGRTAHSR FKIPLNTEDG GVCSFTKQSG
TAKLLMRASL IIWDEASMTK RHAVEALDNS MRDIMARPDL PFGGKTIVFG GDFRQVLPVV
RKGTRSQITD ATLRKSYLWE NMRQLRLVRN MRAQSDPWFA DYLLSVGNGT EDTVDDDYIR
LPDEICVPYT SDATDIDKLI ESVFQMTLEE NLLDPNYITS RAILSTRNEY VDKINMKMIE
RFPGEEMIYY SFDHAEDDPH NYYPAEFLNS LTPNGLPPHI LKLKINCPII LLRNIDPASG
LCNGTRLIVR GFMRNAIDAE IVLGQHASKR VFLPRIPLCP SDDEMFPFRF KRKQFPVRLS
FAMTINKAQG QTIPNVGVYL PEPVFSHGQL YVALSRATSR SNMKILTVPD KKRKASPTPL
QILQRT
//
