ID   A0A453CMK8_AEGTS        Unreviewed;       494 AA.
AC   A0A453CMK8;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
OS   Aegilops tauschii subsp. strangulata (Goatgrass).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX   NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET2Gv20898800.13, ECO:0000313|Proteomes:UP000015105};
RN   [1] {ECO:0000313|Proteomes:UP000015105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX   PubMed=25035499; DOI=10.1126/science.1250092;
RG   International Wheat Genome Sequencing Consortium,;
RA   Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA   Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT   "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL   Science 345:1250092-1250092(2014).
RN   [2] {ECO:0000313|Proteomes:UP000015105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX   PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA   Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA   Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT   "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL   Nat. Plants 3:946-955(2017).
RN   [3] {ECO:0000313|EnsemblPlants:AET2Gv20898800.13}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (MAR-2019) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   AlphaFoldDB; A0A453CMK8; -.
DR   EnsemblPlants; AET2Gv20898800.13; AET2Gv20898800.13; AET2Gv20898800.
DR   Gramene; AET2Gv20898800.13; AET2Gv20898800.13; AET2Gv20898800.
DR   Proteomes; UP000015105; Chromosome 2D.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR   InterPro; IPR032190; NPC1_N.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR   PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR   Pfam; PF16414; NPC1_N; 1.
DR   Pfam; PF02460; Patched; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        172..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        418..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        443..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        472..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          417..494
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          117..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   494 AA;  54250 MW;  032BC2625F07B4EE CRC64;
     EWFAFLGRQA NPNEPGSPYL ITYRPDLSDS SGVKPLNTTV YSCGDPSLGC SCGDCPSSSV
     CMGSLLPQSK TETSCSVKMG SLKAECLDFS LVVVYIVFLC AILLWGLLYR TRGRTGFPSQ
     TKPPKNADDK SNNNGNVPEN SAQVPKAASS SIVQTYMSTF FRRHGVFVTR HPLLVLCASL
     LVPILLCIGL IRFKVETRPE KLWVSPGSQT AYEKQYFDSH LAPFYRIEQL VLATSASDQL
     EAPTIVNDNN FKLLFQIQKK IDDLRANYSG STVSLADICL KPLSTDCATQ SVLQYFQLDP
     KKHDDLGIDH AKFCFEHYSS EETCLSTFQS PIDPSTILGG FPGSNFTEAS AFVITYPVNN
     KVETTGQENA KAMAWERAYI NLVKEEILPM VLAQNLTLSF SSESSIKDEL NRESTADAIT
     IVISYIVMFA YISFTLGDRP SRLWALFVSS KVLLGLSGVV LVMLSVLGSM GFFSAVGVKS
     TLIIMEVIPF LVLA
//