ID A0A453DMI1_AEGTS Unreviewed; 196 AA.
AC A0A453DMI1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Probable magnesium transporter {ECO:0000256|RuleBase:RU363078};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET2Gv21309400.6, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET2Gv21309400.6}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- FUNCTION: Acts as a Mg(2+) transporter. Can also transport other
CC divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but
CC to a much less extent than Mg(2+). {ECO:0000256|ARBA:ARBA00025284,
CC ECO:0000256|RuleBase:RU363078}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738,
CC ECO:0000256|RuleBase:RU363078}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363078};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363078}. Early
CC endosome {ECO:0000256|RuleBase:RU363078}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NIPA (TC 2.A.7) family.
CC {ECO:0000256|ARBA:ARBA00007001, ECO:0000256|RuleBase:RU363078}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363078}.
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DR AlphaFoldDB; A0A453DMI1; -.
DR EnsemblPlants; AET2Gv21309400.6; AET2Gv21309400.6; AET2Gv21309400.
DR Gramene; AET2Gv21309400.6; AET2Gv21309400.6; AET2Gv21309400.
DR Proteomes; UP000015105; Chromosome 2D.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF96; MAGNESIUM TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU363078};
KW Endosome {ECO:0000256|RuleBase:RU363078};
KW Ion transport {ECO:0000256|RuleBase:RU363078};
KW Magnesium {ECO:0000256|RuleBase:RU363078};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363078};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363078};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363078}; Transport {ECO:0000256|RuleBase:RU363078}.
FT TRANSMEM 14..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 54..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 78..102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 114..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
SQ SEQUENCE 196 AA; 20716 MW; AEAAABD899AC33A4 CRC64;
GGGRWYTGMS SDNIKGLVLA ISSSLFIGAS FIIKKKGLKK AASSSGGVRA GVGGYSYLYE
PLWWVGMITM VVGEVANFVA YAFAPAILVT PLGALSIIIS AVLAHVMLRE KLHIFGILGC
VLCVVGSTTI VLHAPQERQI ESVTEVWGLA TEPAFMCYVG VVLAIVALLV FKFVPLYGQT
HVMVYIGVCS LVGSIS
//
