ID A0A453FSR5_AEGTS Unreviewed; 1076 AA.
AC A0A453FSR5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=VHS domain-containing protein {ECO:0000259|PROSITE:PS50179};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET3Gv20769300.5, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET3Gv20769300.5}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR AlphaFoldDB; A0A453FSR5; -.
DR EnsemblPlants; AET3Gv20769300.5; AET3Gv20769300.5; AET3Gv20769300.
DR Gramene; AET3Gv20769300.5; AET3Gv20769300.5; AET3Gv20769300.
DR Proteomes; UP000015105; Chromosome 3D.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0099080; C:supramolecular complex; IEA:UniProt.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 2.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 275..313
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 686..792
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT REGION 64..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1076 AA; 117902 MW; 424E221752530762 CRC64;
MLPELFDHPD QNVRASSKGL TLELCRWIGK EPVKSILFEK MRDTMKKELE AELANVSGIA
KPTRKIRSEQ EKELEEEAVP ETTGASTSEV AVPDAPMEID EYDLVDPVDI LTPLEKSGFW
DGVKATKWSE RRDAVAELTK LASTKKIAPG DFNEVSRTLK KLVTDVNLAV AVEATQAIGN
LAKGLRTHFS GNSRNLLPVL LEKLKEKKPT MSEALTQTLE AMHKSGCIAL LDVIEDVRVA
VKNKVPLVRS LTLNWVAFCI ETSNKATVLK LHKEYVPICM ECLNDSTPDV RDSSFSVLTA
IAKMVGMKPL ERSLEKLDDV RKKKLSDMIG SATDTVLSSG TVPTSSSGAA TSAREVTDSS
TMRRSAASML SGKKPIHAAA PAKKSGPAKS TAKKTDGGPQ SKASAAPEIE DVEPSEMSLE
EIEERLNSVV KTETISQLKS TVWKERLEAI GMLKQDVENL TELDKSAELL VRLLCAVPGW
NEKNVQVQQQ VIEVITYIAS TVKKFPKRCV VLCLLGISER VADIKTRAPA MKCLTAFCEA
VGPGFVFERL YKIMKEHKNP KVLSEGILWM VSAVEDFGTS NLKLKDIIDF CKDTGLQSSA
AATRNSTIKL IGMLHKFVGP DIKGFLSDVK PALLSALDAE YEKNPFEGAA APPKRTVRAL
DTASSTSAAS SDGLPREDIS SKITPALLKN LGSPDWKLRL ESIEAVNKIV EEAHKRIQPT
GTVDLFTALR GRLNDSNKNL VMATLSSIGV LASAMGPSVE KSSKGILADV LKCIGDNKKH
MRECTLTALD SWVAATQLDK MVPYIAVALG DQKSGSEGRK DLFDWLSKHV SKMSDPAEAL
PLLKPSASSL MDKSSEVRKA AETFMNEVLK ICGQAAVAKN LRDLPSPTMA IVAERLKLSS
VHEGISDSVK TVTTSMSLPS KGGLKNIKPG LNDRSSNVGK AASQRGVPAR ASVTMISSQD
SLQSQALFNI KDSNKVGQHQ VLQLAKLYIE FLYLYLYLIV QEDRERRVLV RKFKFEEPRR
EQIDELKVDL FKHFREDVSL RLWNSDFKRQ IDGIELLQKV GIGNIRTYSC AVNCAT
//
