ID A0A453GU24_AEGTS Unreviewed; 320 AA.
AC A0A453GU24;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=UMP kinase {ECO:0000256|ARBA:ARBA00012899};
DE EC=2.7.4.22 {ECO:0000256|ARBA:ARBA00012899};
DE AltName: Full=Uridine monophosphate kinase {ECO:0000256|ARBA:ARBA00032092};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET3Gv21207500.4, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET3Gv21207500.4}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway;
CC UDP from UMP (UMPK route): step 1/1. {ECO:0000256|ARBA:ARBA00004791}.
CC -!- SIMILARITY: Belongs to the UMP kinase family.
CC {ECO:0000256|ARBA:ARBA00007614}.
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DR AlphaFoldDB; A0A453GU24; -.
DR STRING; 200361.A0A453GU24; -.
DR EnsemblPlants; AET3Gv21207500.4; AET3Gv21207500.4; AET3Gv21207500.
DR Gramene; AET3Gv21207500.4; AET3Gv21207500.4; AET3Gv21207500.
DR UniPathway; UPA00159; UER00275.
DR Proteomes; UP000015105; Chromosome 3D.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0033862; F:UMP kinase activity; IEA:InterPro.
DR GO; GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04254; AAK_UMPK-PyrH-Ec; 1.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR HAMAP; MF_01220_B; PyrH_B; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR015963; Uridylate_kinase_bac.
DR NCBIfam; TIGR02075; pyrH_bact; 1.
DR PANTHER; PTHR42833; URIDYLATE KINASE; 1.
DR PANTHER; PTHR42833:SF4; URIDYLATE KINASE PUMPKIN, CHLOROPLASTIC; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 64..273
FT /note="Aspartate/glutamate/uridylate kinase"
FT /evidence="ECO:0000259|Pfam:PF00696"
SQ SEQUENCE 320 AA; 34442 MW; 1F15F821D1155F2E CRC64;
ALLNPGVGCG IAAKASPIGD AFNTFHDAPC PLSFGRSQAS LMPPFSGLML DESSRSKRPY
KWQRVLLKVS GEALAGDHTE NIDPKVTMAI AREVASVTKL GVEVAIVVGG GNIFRGASWA
GCSGLDRSSA DYIGMMATVM NAIFLQATME SIGIPTRVQT AFRISEVAEP YIRRRAIRHL
EKGRVVIFAA GTGNPFFTTD TAAALRCAEI NAEVVLKATN VDGVYDANPK HNPNARILET
VSYNEVISRD LSVMDMTAVT LCQENNIPVV VFNLQNTGNI AKAIVGEKVG TFIGCTRNLE
YRESTEGSLD QEDKILVSEW
//
