ID   A0A453H4Y1_AEGTS        Unreviewed;       716 AA.
AC   A0A453H4Y1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Chloride channel protein {ECO:0008006|Google:ProtNLM};
OS   Aegilops tauschii subsp. strangulata (Goatgrass).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX   NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET4Gv20067600.37, ECO:0000313|Proteomes:UP000015105};
RN   [1] {ECO:0000313|Proteomes:UP000015105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX   PubMed=25035499; DOI=10.1126/science.1250092;
RG   International Wheat Genome Sequencing Consortium,;
RA   Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA   Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT   "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL   Science 345:1250092-1250092(2014).
RN   [2] {ECO:0000313|Proteomes:UP000015105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX   PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA   Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA   Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT   "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL   Nat. Plants 3:946-955(2017).
RN   [3] {ECO:0000313|EnsemblPlants:AET4Gv20067600.37}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (MAR-2019) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A453H4Y1; -.
DR   EnsemblPlants; AET4Gv20067600.37; AET4Gv20067600.37; AET4Gv20067600.
DR   Gramene; AET4Gv20067600.37; AET4Gv20067600.37; AET4Gv20067600.
DR   Proteomes; UP000015105; Chromosome 4D.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd03685; ClC_6_like; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002251; Cl_channel_pln.
DR   PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR   PANTHER; PTHR11689:SF136; H(+)_CL(-) EXCHANGE TRANSPORTER 6; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01120; CLCHANNELPLT.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        71..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   716 AA;  78278 MW;  999A41C1DE5DD88A CRC64;
     DGIGMARLAW SRLPTADGAA PLPEGPAASA PAQDELFVGA VESLDYEVIE NYAYREEQAQ
     RSKFWVPYYI MLKWFFALLI GVGTGLAAIF INLAVENFSG WKFTLTFAII QHSYFVGFLV
     YILLNLALVF SSVYIVTQFA PAAAGSGIPE IKGYLNGVDT HGILLFRTLV GKIFGSIGSV
     GGGLALGKEG PLVHTGACIA SLLGQGGSAK YHLNSRWVQI FESDRDRRDL VTCGCAAGVA
     AAFRAPVGGV LFALEEVTSW WRSHLMWRVF FTSAVVAVVV RSAMNWCDSG KCGHFGAGGF
     IIWDISGGQE DYSYQELLPV AIIGVIGGLL GALFNQLTLY ITKWRRTYLH KKGKRVQIFE
     ACLISLITST VSFVLPLLRK CSPCPELETN SGIQCPHPPG TDGNFVNFYC SKDNEYNDLA
     TIFFNSQDDA IRNLFSAKTF HEYSAQSLIT FLVMFYSLAV VTFGTAVPAG QFVPGIMIGS
     TYGRLVGMSV VKFYKKLNVD EGTYALLGAA SFLGGSMRMT VSLCVIMVEI TNNLQLLPLI
     MLVLLISKAV GDFFNEGLYE EQARLKGIPL LDSRPKQVMR NMNAKDACKN QKVVCLPRVS
     RVVDIVSVLQ SNKHNGFPIV ERGQNGESLV IGLILRSHLL VLLQSKVDFQ NTPFPCGPGI
     LNRHNFSDFV KPASSKGKSI DDIHLTDEEL GLYLDLAPFL NPSPYIVPED MSLAKV
//