ID A0A453I5E5_AEGTS Unreviewed; 922 AA.
AC A0A453I5E5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Peptidase M16 N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET4Gv20450600.3, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET4Gv20450600.3}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR AlphaFoldDB; A0A453I5E5; -.
DR EnsemblPlants; AET4Gv20450600.3; AET4Gv20450600.3; AET4Gv20450600.
DR Gramene; AET4Gv20450600.3; AET4Gv20450600.3; AET4Gv20450600.
DR Proteomes; UP000015105; Chromosome 4D.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..132
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 153..333
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 340..625
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 630..815
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 922 AA; 105354 MW; F660822FC9860E25 CRC64;
QAAAAVCVGM GSFADPPKAQ GLAHFLEHML FMGSSVFPDE NEYDSYLSKH GGSSNAFTET
EYTCYHFEVN REYLKGALDR FSQFFVSPLV KAEAMDREIL AVDSEFNQVL QSDSCRLYQL
QSHTCSQGHP LNRFTWGNKK SLSNAMGSGI NLREEILQMY MSNYHGGMMK LVIIGGEPLD
TLEAWTMELF SEVKAGPLLE ISPKTDMPFW KSGKLYKLEA VRDVHSLFLS WTLPCLHKEY
MKKPEDYLAH LLGHEGKGSL LYFLKAKGWA STLSAGVGTG GTQRSSYAYI FEMSIRLSDS
GLKNLFEVIT AVYQYINLLK QSEPQEWIFK ELQDIGYMEF RFAEEQPPDD YVVDLAENML
FYSEKHIISG EYIYEGWEPE LVKHVLSFFH PDNMRVDILS RSFDKQSQAI RCEPWFGSQY
IEEDIPSSLI ESWRNPVEID GNFHLPRKNE YIPGDFSLRN ASIPKSSNDD NPRCIVDEPF
IKLWHKMDIT FNVPRANAYF LISVKDGCSS LRNSVLTDLF ANLLKDELNE VLYQAYVAKL
ETSLSVVGSN LELKLYGYND KLAILLSHIL AASQSFSPKI DRFEVIKEDL ERAYRNTNMK
PMSHSTYLRL QFLRQIFWDV NEKLKVLATL TFSDLAAFVP ELLSQLHIEG LCHGNLSGDE
AINISKIFQN TLSGQTLSVE ARHGERVLCI PHGANFIRSV RVKNDLEENS VVEVYFPVEQ
DIGKDSTRLR AITDLFSNII EEPCFDQLRT KEQLGYTVDS SPRMTYRLLA YCFRVMSSKY
SPVYLQSRID NFIDGLSALL DGLEEETFEH HKSGLIAQKL EKDPSLSYQT GDYWSQITDK
RYMFDMSKLE AEELRTVGKE DVISWYNAYI RSSSPTRRRL AIHVYGCNSD IAEAAKLQEQ
SWTAIDDVES LKGSSQFYPS LC
//
