ID A0A453IPX8_AEGTS Unreviewed; 1211 AA.
AC A0A453IPX8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA repair protein UVH3 {ECO:0008006|Google:ProtNLM};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET4Gv20637700.19, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET4Gv20637700.19}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
CC {ECO:0000256|ARBA:ARBA00005283}.
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DR AlphaFoldDB; A0A453IPX8; -.
DR EnsemblPlants; AET4Gv20637700.19; AET4Gv20637700.19; AET4Gv20637700.
DR Gramene; AET4Gv20637700.19; AET4Gv20637700.19; AET4Gv20637700.
DR Proteomes; UP000015105; Chromosome 4D.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd09904; H3TH_XPG; 1.
DR CDD; cd09868; PIN_XPG_RAD2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR16171:SF7; DNA EXCISION REPAIR PROTEIN ERCC-5; 1.
DR PANTHER; PTHR16171; DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105}.
FT DOMAIN 1..98
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 884..953
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 127..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..648
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1040
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 135217 MW; 021EFBB2CCCC24C3 CRC64;
MGVHGLWGLL APVGRRVSVE TLAGKRLAVD ASIWMVQFMR AMRDDKGDMV RDAHILGFLR
RICKLLFLRA RPVFVFDGAT PALKRRTLAA RRRNRDAAQA KVRKTAEKLL ISHLKASRLE
ELAAQIKSDR AKHDAKGKQV ESSRGEETEK TDGGQNRNDD GENSRGAAAP INQEKLDELL
AASLAAEDEA GLTGKGEHNP ASVPSQEGTG IDEDENDDDE EMIFPITTGD IDPAVLASLP
PSMQLDLLVQ MRERVMAENR QKYQKIKKEP AKFSELQIQS YLKTVAFRRE IEEVRKGAAG
KDVGGIQTSK IASEANREFI FSSSFTGDKQ TLAQRGVEEQ IVDSCKSKRE ISSAIFKSSP
SSSSRSIKPH SGEPSTGFGP DVETYRDERG RVRVSRVRGM GIRMTRDIQR NLDFIKEHEQ
AKSMGQANIG KGSTSNEEPP DFPEHLFEND GLQSSVGLSE DFAETIGDNH HTSSLVGGSD
DISEGSCHGS KETIEISFVD DQIGVKDNDD KLFLHLVSGT SSKLFADDDR LAKNTEESDN
SEGIWEEGII EEETLPMKVD EKDYQSSPPD NCCTDDEVEW EEGVCDVREV PSSEYNQCKL
PKGDIEEEAL IQEAIKRSLE DSEKQEFENG VPEDLKTPIE DKSLQSHDNV PKPSEAPATP
YSHSEASFVE ETIKETGIKN SSGEDGVMHD PEVLEAERKE NEKQAQLESN DGRAASNTDY
SQESSPVYNV STSTLTARPS CSPKVQDNDA IVSATSIHEC PKEEVIKQNT SNSHKSECNK
NDPYIGDISM AAQKEPLMDE LVAGDAVQKE NIIQEDMNVT TSEINSTQLN ENYDSHIISE
NNLEKEISFL RQEQLDLGNE RRKLESHAES VSSEMFAECQ ELLQMFGLPY IIAPMEAEAQ
CAYMEINNLV DGVVTDDSDV FLFGARNVYK NIFDDRKYVE TYLMKDIESE LGLTREQLIR
MALLLGSDYT EGISGIGIVN AIEVVHAFPE EDGLQQFREW IESPDPAILG KFDVETSGSS
KRRKSGGNEF CEKRNSQEPE CVEGSDNNQS SNETQHIKEV FMSNHRNVSK NWHIPTTFPS
ETVISAYISP QVDDSTERFS WGRPDLSLLR KLCWERFGWN KEKADELLLP VLKEYNKHET
QLRMEAFYSF NERFAKIRSK RIQKAIKGIT GKTFSETDEL NEDSPSTSDA PNKKEAGRSS
RAKPKGKRNT T
//
