ID A0A453JX93_AEGTS Unreviewed; 853 AA.
AC A0A453JX93;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Zinc-hook domain-containing protein {ECO:0000259|PROSITE:PS51131};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET5Gv20219500.2, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET5Gv20219500.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A453JX93; -.
DR EnsemblPlants; AET5Gv20219500.2; AET5Gv20219500.2; AET5Gv20219500.
DR Gramene; AET5Gv20219500.2; AET5Gv20219500.2; AET5Gv20219500.
DR Proteomes; UP000015105; Chromosome 5D.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR013134; Zn_hook_RAD50.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51131; ZN_HOOK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00471}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00471}.
FT DOMAIN 648..747
FT /note="Zinc-hook"
FT /evidence="ECO:0000259|PROSITE:PS51131"
FT COILED 228..262
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 291..336
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 451..478
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 538..565
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 595..629
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 695
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
FT BINDING 698
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
SQ SEQUENCE 853 AA; 98196 MW; 6B0C6F53A0B34D07 CRC64;
MSTVDKMLIK GIRSFDPENK NVITFFKPLT LIVGSNGAGK TTIIECLKLS CTGELPPNSR
SGHTFVHDPK VAGETETKGQ IKLRFKTAAG KDVVCIRSFQ LTQKASKMEF KAIESVLQTI
NPHTGEKVCL SYRCADMDRE IPALMGVSKA ILENVIFVHQ DESNWPLQDP STLKKKFDDI
FSATRYTKAL EVIKKLHKDQ AQEIKTFRLK LENLQTLKDQ AYRLRDSIAQ DQEKSDALKT
QMEDLKTNIQ AVENKILRTE TSMVDLRKLQ EQISTKATAR STYFTLQQQQ YAALSEENED
TDEELKEWQT KFEEKIALLE TKIAKLEREM NDEYAKSSLL SETINDSTRE IGKLQAEADA
HMSVKHERDS AIRTIFNKHN LGPVPDAPFT NDIAMNLTNR TKARLSNLED DLQEKKKTNE
TQLEFLWGRY LKVNARYSEV DGQIQSKKES KIGVLRRIKD KENERDAAET ELSRHNLARI
DERERHLQIE VERKTIALGE RDYDLIISQK RSEIYTLDHK IKALHREKDN IATDADDRVK
LELKKDELEK CKKKLKKIYD EHKDKFRSVL KGRLPHEKDV KKEITQAFGS VDSEYNDLNS
KSQEAEQQLK LAQMKIDAAK SHLAKLQKVL DAKRKHLNSK LQSIAKVSVD INAYPKILKD
AMDERDKQTN NFSYAKGMRQ MYEPFEKVAR QHHKCPCCDR AFTPDEEDLF VKKQRTTGTS
TAERLKVLAE NLSVAEDLFN QLDNLRVIYD EYVKLEKETI PLAEKDLEQL SADKSEKEQI
SDDLVSVLAQ VKMDRDGVEV LLRPVDTIDR HVQEIQELEP QVKDLEYKLD SRGQGVKSVD
EIQLELISVQ RAR
//
