ID A0A453LK44_AEGTS Unreviewed; 1027 AA.
AC A0A453LK44;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 08-NOV-2023, entry version 19.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET5Gv20819000.22, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET5Gv20819000.22}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR AlphaFoldDB; A0A453LK44; -.
DR EnsemblPlants; AET5Gv20819000.22; AET5Gv20819000.22; AET5Gv20819000.
DR Gramene; AET5Gv20819000.22; AET5Gv20819000.22; AET5Gv20819000.
DR Proteomes; UP000015105; Chromosome 5D.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105}.
FT DOMAIN 234..370
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..875
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1027 AA; 115558 MW; 6AEA9773116A25CA CRC64;
PPPSQLRPRF RPLGSQDTSM QSIKRLPRSV HSSLRSSIIL SDLPRVVEEL VYNSIDANAR
KIDVSVNVRA CYVKVEDDGC GIARDELVLL GEKYATSKFH DVMGDEESSS RSFGLNGEAL
ASLSDISVVE VRTKARGRPN SYCKIIKGSK CSHLGIDDQR EAVGTTVVAR ELFYNQPVRR
KQMQSGHKRE LHNVKKCVLQ IALIHPQLSV RLLDTDSEDQ LLYTVPSSSP LPLISDSFGN
DVSSCLHEIS TSHQSWALSG HISGPTNVFC NKDFQYLYIN SRFVSRSPIH NILNSLAASF
QSSITRTIEE TDIQSRKRQK TDVYPAFLLN FFCPRSSYDL HFEPSKTIVE FKDWQSILFF
FEQTITNYWK KHVPQSSKGK AIDDTCVPLK SDVKSNRAFL KHQNVQNKED DAYLQHHTPR
KSSVRESNFG TGAATAPKDL DYFSFDMKPS PWHVCYPDRI SDASEHSDNV ARNDLTHFSE
RVSYQWLEDG SSELEDCGLS GANPTVWKKR RMEGIFHGHA YSCEVGNFED VQTEGLSAYN
QESEIMGPEI DLQEPRFGVV NRPNRITCDF MHNETNINAN MSGCDGLYTE FDRFDDDCLL
NEVTKTMGDI SCPEMPHFSD GFYHEGCSTP IILKRCSTRK QLGTAAGYVD DLETNAIAQM
NFPDIHAVWE SDAMDMSSIK DNHLHLSHPF LLPDTPSSQS HARTGLELQG RSSKSFASWN
CENMDSDFRS TWDRFNSNSS RICEGSKHFN NLDDEPQSPN YFNHVDQFVS EDDEIPWKSK
ISAPLSHIIS PEKSTNGCQS NGSSSHLANN SVLIKDLPNQ DNFGCDRRSR FSKGRSRSCS
APPFYKGKRK FPGLNQPRTK LTADGDKDIP IKDSEETAPA PENISHMSAT QPIPETCSSE
LSGLNFSLKG NVKMHEETCS DGLENFTAQI TKWRDDSDQH TALELPHIPS ACYDDILNIS
SGPLHLSSSS LVPECIDKNC FEEARVLLQL DKKFIPVISG EMLLLVDQHA ADERIRLEEL
RSKGFIR
//
