ID A0A453LY87_AEGTS Unreviewed; 1232 AA.
AC A0A453LY87;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET5Gv20978100.25, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET5Gv20978100.25}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; A0A453LY87; -.
DR EnsemblPlants; AET5Gv20978100.25; AET5Gv20978100.25; AET5Gv20978100.
DR Gramene; AET5Gv20978100.25; AET5Gv20978100.25; AET5Gv20978100.
DR Proteomes; UP000015105; Chromosome 5D.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1095; OS05G0250700 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 49..131
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 216..439
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 1137..1227
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1232 AA; 138871 MW; 918CB4E94C478D46 CRC64;
YFSVFAVLHN TNEAGFCFAL NLLYSTTSQV TEAAAMGMGL EDLASYVESM LTEMAREKVG
LLLGVSSEIQ SMENKLRFLK DYFADADRRV IADESVRDWV AQLKQIMYGA TDIIDLCQHE
AMERGPSATR VVRRFTPLLF CIRNPSVAHD IGSRIKALNQ RLDAIMERSA AFNFLSRRDM
DHGGEVHTSH PYNFKTSGEL DRSDVVGEKI EEATEALVAE IIKTRNEVNN DIAVVAIVGV
CGIGKTTLAQ KVFNDEAIQG EFDKKIWLSI NKHFNKADLL RTAITQAGGD SCPTNDEMDM
LVDILADALA GKKVLLVMDD VWYPTAWECV LKKPFFNAAA RGSRVLITTR REDVARRMRA
QHPCHRVDKL GPEDAWSLMK KQIMGNNTHE TELDELKDIG LQIIANCGGL PLAIKVMGGV
LSVRHVQRPD WMRVLNDFIP SCELPEVINH SVYLSYEDLA PCLKQCFLHY SLLPTNAVFY
ENDIVGMWIS EGFIHGNSHD YWRDSEDLGS EYYRELILRN LIEPDARYTS QLVCNMNDVV
RSFAQSICRD EALVAHNGDM YGYLSSRKFY QLSLESKELE SDMLVWSLVQ EQTSLRTLVS
IGQIKLKPGD SLMAFPSPRT LHIESTNAAV LVESLCQLKH LRYLSVAHTD VSSLPENINT
MKFLQHINLQ GCESFEKLPD SIIKLEQLRY LNLNDTGINV IPRGFCILTN LSKLYGFPAY
MDGNWCSLEE LWPLSRLKEI ELKGLDNVAA GLFAESASLY QMRLSYLKLE CSTRVGGGGL
VIEGRSVFQD EENQRIEAVF DELHPPQRLS TLVIQGYFGL QLPVWMRTED RLECLVVLTM
EDLACCTQLP CCLSQLPYLE VLKIQRAPAI SCVGPEFLGV SEHHDQTAIM FPRLHELVFS
GMVKWEEWVW EKQLNAMPAL EELLVDNCKL RSFPPGLAFR ARALRRLVVT AAQNLNSLDS
FASVVELDVY FSPTLTSIAN LHQLQKLTII FCPKLEKLIG VPAIRRLVLE DYDMETLPRY
LQDVGNLSLL QLDCSLELLT SIAMGQPGPE WKKYSHVKHV EAYAHDGDNQ REWYVLYTKD
PYKFETNINQ RSSKLAAVGK GEDKLIGKEA EQLLGIDSSS DSAVSEDNSE LVGIENPCQS
IIKLLTHGDE EELKMVSICG TGGLGKTTVA HAVYRKIANE FKYNFFVDMP RNLDIKVIIG
TICAEVGCPR PKFEECGVQQ LVDRLKIFFE GK
//
