ID A0A453MA51_AEGTS Unreviewed; 1048 AA.
AC A0A453MA51;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET5Gv21115200.7, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET5Gv21115200.7}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR AlphaFoldDB; A0A453MA51; -.
DR STRING; 200361.A0A453MA51; -.
DR EnsemblPlants; AET5Gv21115200.7; AET5Gv21115200.7; AET5Gv21115200.
DR Gramene; AET5Gv21115200.7; AET5Gv21115200.7; AET5Gv21115200.
DR Proteomes; UP000015105; Chromosome 5D.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProt.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Signal {ECO:0000256|RuleBase:RU361199};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT CHAIN 22..1048
FT /note="Alpha-mannosidase"
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT /id="PRO_5018809958"
FT DOMAIN 362..436
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1048 AA; 117488 MW; 55D9B75B3089047C CRC64;
MGPVRLALLL LLLAAAAVVL GPGGGGEAVY IPYNTSAGVV NGKLNVHVVP HTHDDVGWLK
TVDQYYVGSN NSIQNACVQN VLDSLVPALL KDENRKFIYV EQAFFQRWWR QQSDMIKDTV
KGLVSSGRLE FINGGMCMHD EATVHYIDMI DQTTLGHRFI KEEFGQIPRI GWQIDPFGHS
AVQAYLLGAE VGFDALYFFR IDYQDRDTRN GTKELEVVWR GSKTFGSSAD IFAGIFPKNY
EPPPGEFYFE VDDTSPVVQD DPLLFDYNVE QRVNDFVAAA LAQANVTRTN HIMFTMGTDF
KYQYAESWFR QMDKLIHYVN KDGRVNALYS TPSIYTDAKF STNEPWPLKT NDFFPYADNP
NAYWTGYFTS RPALKRYVRM MSGYYLAARQ LEFFIGRSKS GSTTDSLGDA LALAQHHDAV
TGTEKQHVAN DYAKRLSIGY KKAEELVSTS LGCLSESGSN SRCSSPTTKF VQCPLLNITY
CPPSEMNLSQ GKSLVVLVYN SLGWKREDVL RIPVMSDSIV VHDSEGREIE SQLLPIANAS
SHLRDRHVKA YLGTSPAASP KFWVAFPASV APLGFSTYFI SIGKRSASIS STSTLNSQGS
ESRNLQVGQG RLKLQYDAAG ALSQYSDSKT QVEANFEQKY KYYLGQDGSG DDPQASGAYI
FRPKGVVPIK TDGQVPPTIL RGPILDEVHQ QINPWIYQIT RVYKGKDYVE TEFIVGPIPV
DDENGKELST EIITSMATNK TFYTDSSGRD FIKRVRDYRS EWKIEVNQPV AGNYYPINLG
IYVEDGSKEL SILVDRSVGG SSIKDGQIEL MLHRRLLNDD GRGVAEALDE KVCLDDQCEG
LVIEGKYYLK IDPQGDGARW RRTFGQELYS PLLLAFAEKV QHKFCCTRDR SNSYSCRIEH
APTCFSRMEA TGGIHMFHHS LEWIQLTAFL KMSRCLLLRE LEDGSVLLRL AHLYEAGEHK
DLSAPASVDL KRVFPDKKIG KIIETSLSAN QERAAMEKKR LKWKVAGPPP KENVVRGGPL
DPSKLVVELA PMEIRTFVIN FDHRLAAH
//
