ID A0A453MAP1_AEGTS Unreviewed; 963 AA.
AC A0A453MAP1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET5Gv21115200.18, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET5Gv21115200.18}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR AlphaFoldDB; A0A453MAP1; -.
DR EnsemblPlants; AET5Gv21115200.18; AET5Gv21115200.18; AET5Gv21115200.
DR Gramene; AET5Gv21115200.18; AET5Gv21115200.18; AET5Gv21115200.
DR Proteomes; UP000015105; Chromosome 5D.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProt.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT DOMAIN 344..418
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 963 AA; 108579 MW; F1CEBF03914F219D CRC64;
VLGPGGGGEA VYIPYNTSAG VVNGKLNVHV VPHTHDDVGW LKTVDQYYVG SNNSIQNACV
QNVLDSLVPA LLKDENRKFI YVEQAFFQRW WRQQSDMIKD TVKGLVSSGR LEFINGGMCM
HDEATVHYID MIDQTTLGHR FIKEEFGQIP RIGWQIDPFG HSAVQAYLLG AEVGFDALYF
FRIDYQDRDT RNGTKELEVV WRGSKTFGSS ADIFAGIFPK NYEPPPGEFY FEVDDTSPVV
QDDPLLFDYN VEQRVNDFVA AALAQANVTR TNHIMFTMGT DFKYQYAESW FRQMDKLIHY
VNKDGRVNAL YSTPSIYTDA KFSTNEPWPL KTNDFFPYAD NPNAYWTGYF TSRPALKRYV
RMMSGYYLAA RQLEFFIGRS KSGSTTDSLG DALALAQHHD AVTGTEKQHV ANDYAKRLSI
GYKKAEELVS TSLGCLSESG SNSRCSSPTT KFVQCPLLNI TYCPPSEMNL SQGKSLVVLV
YNSLGWKRED VLRIPVMSDS IVVHDSEGRE IESQLLPIAN ASSHLRDRHV KAYLGTSPAA
SPKFWVAFPA SVAPLGFSTY FISIGKRSAS ISSTSTLNSQ GSESRNLQVG QGRLKLQYDA
AGALSQYSDS KTQVEANFEQ KYKYYLGQDG SGDDPQASGA YIFRPKGVVP IKTDGQVPPT
ILRGPILDEV HQQINPWIYQ ITRVYKGKDY VETEFIVGPI PVDDENGKEL STEIITSMAT
NKTFYTDSSG RDFIKRVRDY RSEWKIEVNQ PVAGNYYPIN LGIYVEDGSK ELSILVDRSV
GGSSIKDGQI ELMLHRRLLN DDGRGVAEAL DEKVCLDDQC EGLVIEGKYY LKIDPQGDGA
RWRRTFGQEL YSPLLLAFAE KVQHKFCCTR DRSNSYSCRI EHAPTCFSRM EATGGIHMFH
HSLEWIQLTA FLKMSRCLLL RNSKMEVFSF GWLTYTRLES IRISRPRRVS TSRGYSQIKR
SAR
//
