ID A0A453N2T4_AEGTS Unreviewed; 774 AA.
AC A0A453N2T4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET6Gv20200500.8, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET6Gv20200500.8}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; A0A453N2T4; -.
DR STRING; 200361.A0A453N2T4; -.
DR EnsemblPlants; AET6Gv20200500.8; AET6Gv20200500.8; AET6Gv20200500.
DR Gramene; AET6Gv20200500.8; AET6Gv20200500.8; AET6Gv20200500.
DR Proteomes; UP000015105; Chromosome 6D.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1233; OS09G0365000 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105}.
FT DOMAIN 109..164
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 285..516
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 774 AA; 88623 MW; 1A517C3BCD9F8DF8 CRC64;
LFIAISPAPF FIPTHPRPIF CGGLEAARES VLEVWIIVAC CTPRRSSTAP RQRRNLQIRV
TMSISGTIGV ISGINECVNL FQWARSSISS LHSRWSGKQE QNLQDEVLHL QSGLQCLSDT
LPAMYNLIDR AEWRSHKHCV AELLPKFSDA VYDAEDILDE FRWYEQKVTV EGIASQSAFI
DFFNCVIQGS FNKVKDIQKR LENLSNLLEK MGLGEATPRF DKSVRPETSS FPIETIMFGR
DQELTQVIEL LVVREGDSTT KAHSKGKREC RTINSSKRTL ATINHVCNEQ ENGLAVLPIV
GIGGVGKTTM AQHIYQQVKP HFKKTIWLSV SDDFDVKRLT KEALQSISGE ESTGQLDSLQ
HALHKTVCQK KLLIVLDDLW DDALKENGQS WKRFCAPLKN VRKGSIMLVT TRSQKVADGV
RTMKTLKLNG LKDDVFWNFF KLCMFGSERF SNDHELEQIG RSILPKLKGS PLAAKTLGRL
LRMNRHTTYW NNVLESELWE LRQQEDDILP ALRLSYMYLP FYLKRCFSLC GVYPKDHEFE
KDYLAEIWVA EGFVEPQGDI PIQDIASQYF EDLVSRSFFQ KVHGAYVIHD LLHDMVQMVS
KNDCFILKNV NEFQKIPKNV RHLSVLSNPK FDYSKLLSLC KHEKLRTLIC NMPLEDKVVA
PVMDHWCTEL GRMRVIICAS TTGLPGSVCN LKHLRYLEIS RASPLKSLPS TFCCLYNLQI
LYIGECKIES LPSDFDKLIS LRRIELCGFR YYLEYQLNCD ALEAEQKKRY LHGL
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