ID A0A453N8V8_AEGTS Unreviewed; 1616 AA.
AC A0A453N8V8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET6Gv20278000.7, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET6Gv20278000.7}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- FUNCTION: Acetyltransferase enzyme. Acetylates histones, giving a
CC specific tag for transcriptional activation.
CC {ECO:0000256|ARBA:ARBA00002581}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00000780};
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DR EnsemblPlants; AET6Gv20278000.7; AET6Gv20278000.7; AET6Gv20278000.
DR Gramene; AET6Gv20278000.7; AET6Gv20278000.7; AET6Gv20278000.
DR Proteomes; UP000015105; Chromosome 6D.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15614; PHD_HAC_like; 1.
DR Gene3D; 3.30.60.90; -; 2.
DR Gene3D; 1.20.1020.10; TAZ domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031162; CBP_P300_HAT.
DR InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
DR InterPro; IPR035898; TAZ_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR000197; Znf_TAZ.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR13808; CBP/P300-RELATED; 1.
DR PANTHER; PTHR13808:SF1; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF08214; HAT_KAT11; 1.
DR Pfam; PF02135; zf-TAZ; 2.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM01250; KAT11; 1.
DR SMART; SM00551; ZnF_TAZ; 2.
DR SMART; SM00291; ZnF_ZZ; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF57933; TAZ domain; 2.
DR PROSITE; PS51727; CBP_P300_HAT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50134; ZF_TAZ; 2.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 553..635
FT /note="TAZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50134"
FT DOMAIN 1003..1439
FT /note="CBP/p300-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51727"
FT DOMAIN 1321..1384
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 1441..1493
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 1499..1583
FT /note="TAZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50134"
FT REGION 166..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1591..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1591..1605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1616 AA; 181832 MW; 123C974B4DBF9DCE CRC64;
MMRQPVEPQL QFAIKTLSAQ NQLNQQNQQM SRQMASSSGY STMIPTPGIT QGASGNSRMS
YGTDNMGLSS SGAGMVPQNA NMGTSMPGTM SNGYQHLTTS APLNSTTNSV PSTMGPVGIQ
RQVTHMIPTP GFSNQQNVPT NSDYSNGTGY FNGESAMTPH MQQQKQFQSN QSSHQIQHIG
GHSNSGIHSS MLENSSAFGL SDGHVNGGMG LHGSNTQITN RNAAPEGYMN MSSFGSSPRP
LQQQFNQHPT QRISTSVDMG GSGSFYGTGS SALATANNQN MGAANLQSRS RMNSMLLSNQ
LNMQSIQGQP QIKTEVLDQS EKLNFQPSQL SHEQLLRQQL SMQQHQVQPS SQFVQNQYHL
NQQIPNSQHQ QAMLRSNSFK QSQLNSSHSM QVSEQGTLPH TELTSSQATE PPALPNFQGQ
YQQRSAHDNV KGAQVFGHLS GSQNFSASGS HDSQPLLHPN QQLDVSSSDV SYVLKGTQTE
QMQQHQWRPQ TMEKVPISSN LSLEKQMQDD FCQRAMAQDG AQQPFSSDWR VSGCTVTSVD
PALPKLPAGG LEQPTGNINY LRQMRWLLLL FHAKGCSSPL GSCKLPRCVQ LQDFVKHLDN
CQRKDCPQKK CSKSRMLIEH YKTCVDEQCP VCSNVKKFLR LSAEHASKQK VPEPRKVAQQ
NMTQRIMNGV DSDIMDIDPV SVESFDGQPS VPKRLKMQPA SPNVPEHEIL RASNPQVNPG
FVLQESHPEL LEQNKKTAYM KRELDVKADM RPLQKPVKMG YGADGNVPTA RHNVIPGVSN
EMKSHVKQEI LPVDKGASEN VHEVKNETND STEATALKSG KPKIKGVSLT ELFTPEQINA
HIESLRLWVG QSKAKAEKNQ LLVSSENENS CQLCKVEKLT FEPPPIYCSP CGARIKRNAP
YYTVGSGDTR HFFCIPCYNE SRGDTIEVEG QNFLKARFEK KRNDEETEEW WVQCDKCECW
QHQICALFNG RRNDGGQAEY TCPNCYSNEV KCGLRMPLPQ SAVLGASDLP RTVLSDHIEE
RLFKRLKWER QSRANNSNCS VDEVAGAEGL VVRVVSSVDK KVEVKPRFLE IFQEDNYPTE
FPYKSKAVLL FQKIEGVEVC LFGMYVQEFG ADCAYPNQRR VYLSYLDSVK YFRPEIKAAT
GEALRTFVYH EILIGYLEYC KQRGFTSCYI WACPPLKGED YILYCHPEIQ KTPKSDKLRE
WYLAMLRKAT KEEIVVELTN LYDHFFITMG ECKAKVTASR LPYFDGDYWP GAAEDMINQL
RQEEDDRKLQ KKSKTKKIIT KRALKAAGHT DLSGNASKDA MLMQKLGETI YPMKEDFIMV
HLQYSCSHCC ILMSSGKRWV CHQCRSFYIC DKCYSAEQQL DDRERHPSNS RDTHKLHPVD
IVGVPEETKD RDDILESEFF DTRQAFLSLC QGNHYQYDTL RRAKHSSMMV LYHLHNPTAP
AFVTTCNVCS HDIETGQGWR CEICPDFDVC NGCYQKGAVN HPHKLTNHPS VADRDAQNKE
ARQMRVQQLR KMLDLLVHAS TCRSGSCQYP NCRKVKGLFR HGMQCKTRAS GGCALCKKMW
YMLQLHARAC RDSGCSVPRC RDLKEHLRRL QQQSDSRRRA AVNEMMRQRA AEVATT
//
