ID   A0A453Q9Q0_AEGTS        Unreviewed;       759 AA.
AC   A0A453Q9Q0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
OS   Aegilops tauschii subsp. strangulata (Goatgrass).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX   NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET7Gv20009000.1, ECO:0000313|Proteomes:UP000015105};
RN   [1] {ECO:0000313|Proteomes:UP000015105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX   PubMed=25035499; DOI=10.1126/science.1250092;
RG   International Wheat Genome Sequencing Consortium,;
RA   Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA   Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT   "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL   Science 345:1250092-1250092(2014).
RN   [2] {ECO:0000313|Proteomes:UP000015105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX   PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA   Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA   Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT   "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL   Nat. Plants 3:946-955(2017).
RN   [3] {ECO:0000313|EnsemblPlants:AET7Gv20009000.1}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (MAR-2019) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR   AlphaFoldDB; A0A453Q9Q0; -.
DR   STRING; 200361.A0A453Q9Q0; -.
DR   EnsemblPlants; AET7Gv20009000.1; AET7Gv20009000.1; AET7Gv20009000.
DR   Gramene; AET7Gv20009000.1; AET7Gv20009000.1; AET7Gv20009000.
DR   OMA; QCYSNST; -.
DR   OrthoDB; 341458at2759; -.
DR   Proteomes; UP000015105; Chromosome 7D.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR11764:SF17; TERPENE CYCLASE_MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          100..402
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          418..752
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   759 AA;  85889 MW;  005CE017EB414B9B CRC64;
     MWKLKIAEGG PWLTSGNNHF GRETWEFDRN DAGSSEERDA VDAARAEFQK NRFRTRHSSD
     VLARMQLVKG NNFSLDQQQK PKGDETSVDI NIATVSETLK RALRYFSAIQ GHDGHWPGDF
     PGPLFTTATM IIVLYVTESL GTTLSSEHRK EICRYLYNRQ NMDGGWGLHA EGESSMLSSA
     LNYTALRLLG EDADGGPDMS MPKARKWIHD HGGTTMIPIL GKVWLSVLGV SEWSGVNPMP
     PELFLLPSFV PIQPGRLWSH FRMAFIPMSY LYGKKFVGPI TKLVLSLREE LHIHPYKKIN
     WKQARKLCAK EDAYHPHTWL QECLSDCLYS FGEPFLACWP VSHMRRKALR QIANFLKYED
     DISRYICIGA AQKALSMLCC WSENPSSDAF KRHLARVADF LWLGEDGMKV RVCAGQSWDV
     AFAVQAILAS NVAEEFGTTL RKAHHFIKAS QIVDNPSGDF SRKYRHISKG GWAFQVADQG
     WQVSDCTAEA LKALLLLSKF PSEIVGDQME TCRFHDAVNI LLSLQNPNGG YGTWELARTY
     PWMENLNMTE IYADIMVEHQ YVECTSSVIQ ALALFRQKYP GHREDEVEQC IRRATEFIEK
     LQNEDGSWFG SWGICFTYGT WFAIEGLSAV GQCYSNSTYI RKGCQFLLSK QLRNGGWGES
     HLSSTTKAYT NLDGEKSHIV NTAWAMLALM KAGQAERDPS PLHEAARLIM SMQLGNGDFP
     QEEMIGSFLK NGPLCYMAYR NIFPIWALGE YHRLVLCSG
//