ID A0A453T1V3_AEGTS Unreviewed; 1261 AA.
AC A0A453T1V3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET7Gv21193300.9, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET7Gv21193300.9}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; A0A453T1V3; -.
DR EnsemblPlants; AET7Gv21193300.9; AET7Gv21193300.9; AET7Gv21193300.
DR Gramene; AET7Gv21193300.9; AET7Gv21193300.9; AET7Gv21193300.
DR Proteomes; UP000015105; Chromosome 7D.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1233; OS09G0365000 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105}.
FT DOMAIN 142..205
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 326..553
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 142767 MW; 38F66A846BBF1530 CRC64;
SSASMGVHDG GTRFESTPDE VGGDDRSTHA SMYQETAEPI DYEYKPIIRN PAPSAIGGHA
DRDIWELQNV TQTSKENILD YGPRNSNIRV EGSLHTPVTI GIMDAIGVIS GFKECDYLFQ
WARSTILSQF SGTNEQGLDE ELFRLKNGLQ CLRDTLPAMY ELIDRAEWRS HKHYVAELLP
KLRDGVYDAE DLLDEFRWYM LKVKVDGNGS QSSFMDFFNS VIRGSFNKVD SIQKRLDNIS
MHLRGMGLHD ITIRFDKSVR PETSSFPDET KIFGRDMELK QIIELFCAPR NSSDAHPKRQ
KGNSALDVST STSARNQVGN ESRISDLLVL PIVGIGGVGK TTLAQHICSH EEVESHFDKI
IWVCVSDDFD VKRLTKEVIQ SCSEKYATTE NLNLLQKIFS DIARTEKLLI VLDDMWDDVL
KENRKHWNRF CAPLRNVLPG SMMLITTRSP QVADKVGTMD PITLEGLEDD AFWKFFEVCV
FESGSSSNND PELEHIGRRI VPKLQGSPLA AKTLGRILRM NLQVAHWNDV LESELWKLSQ
EETEILPALR LSYMYLPFRL KRCFSFCAVY PKDYQFQKDR LAEIWVAEGF VEPQGDTPLQ
DIGCEYFNDL LNRSFFQEVH GKYLIHDLLH DMAQKVSEHE CFIVERESDF NDIPPNVRHL
SILFGGDIDN ASLLSLYHLT KLRTLLCEKP LANKKTPASL MEKWLSKLLY LRVIVCDSTN
ELPAIGNLKH LRYLQILSAS PFKSLPAEFC RLYNLQILRL EKCILESLPD DFSSLICLQR
LESHGFQCNS RFRSFQRELY YEVSVDVANG EQGSAFRCIK NINQLGELVM YNIDKQSKEH
AAEAQLQNKK YLEMLNLSWY GLRSPEDNDI EVLRVLQPPT CLKILLLNGY PGVSLPRWSA
SSLSDHINPS EILEVLVDNA NDITGIFPVL TELVIDKCQN LSCLEHILHP DCVPAIREIT
IKDCKNLVSV PAERFGDLRC LEEFTVQGCP NISFRSLVAP SLKRLVLGRG DDYSYEHSCG
NFADNIDCCS LTYFFLSSYH LTSIQLQMWN LPALEELEIS NCESLTSIIG QSGQVLKNTG
GSRAFPSLAS LSIVWCHELS TMDDLLAEDY IPAIEKICIK FCISLKSLPG ERFWKFSSLR
DLEISGCGRL SWKNGFFLPS SLQRLALAQC GDISAWVPDC LENLTSLVTL EISLCRHITS
IPGSLWSTNL TSLENLSIEN CADIVSIGGE NAISEIQNVW ITGCPGMEEL KRPMVRGKRI
P
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