ID A0A453T2M9_AEGTS Unreviewed; 963 AA.
AC A0A453T2M9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET7Gv21205100.3, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET7Gv21205100.3}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR AlphaFoldDB; A0A453T2M9; -.
DR EnsemblPlants; AET7Gv21205100.3; AET7Gv21205100.3; AET7Gv21205100.
DR Gramene; AET7Gv21205100.3; AET7Gv21205100.3; AET7Gv21205100.
DR Proteomes; UP000015105; Chromosome 7D.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..165
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 558..914
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 963 AA; 106973 MW; 016BA91D048BD733 CRC64;
MCFEIFSWIL DHYPEAVKTM DDELLYWICQ SIDEEKDPEC LKLSFHVVEV VMKLFPDPSG
FADQFASDLF EILSKYFPVY FTHGAGDNLG VTRDELSRAL MHAFCASPYF EPFAIPLLLD
KLSSSLPLAK LDSLKYLDNC IHCYGADRMV THASAIWFKL KEVLFSLSSD QLLSSGSPKD
AENNKNQIKS EAEHCLKTAV TYIHSPDRDI FINLILLDED IVNNIHSVTT EEKSIDSSLQ
ALGSVVSILA GSSTYLCTRV FQAHFKRLVD ILGNSAGFDS QHLSIANGSS PAAINYGALY
LSVQMLSSCR EVAVASREGV PAEESWWLIL EEKLDQIIHL FGKLLTIDCQ PTQSAVRKEC
VSCAVKGLLI LATIPEQCSL LLENAYEDIL QMLTLVITSK YENAHFWRLS LKTLTSIGSS
AVELHASKRE MVYNRIVVDK IICLAESCDA SMPLNLRLEA CFEVGTASVN YMLRVARSLE
ETVIRNISQV NGSIECADYV ACLIDCYSSR LLPWFFTSGG LNELALSFAL RLWDEIGDLV
TLDRIISEGL LESLMMGMKL LVGVCTEEQQ SLIVQKACGI VSSMLSLPVK ALTHHLLSVD
ELVPAHSVQD TALVCMLSSV IVGLWPQTPV PEMMMMINLF SVFLLNGHIP AAHALASIFN
KYLQNSEFSH EIKLDKILDV ILGGCFSIVL PSSNLKMSRS SAATSDNADF SDSLPGSIGS
KIDILCGLAW IGKGLLMRGD EKVKEISMFL LKCLSSEASL ASAAADAFHV MMGDSEVCLN
KKFHARIKFL YKQRFFSILM PIFLSKIKET SELTTKLVIY RAFGHIISNA PVSAVITEAH
QILLVMVDIL AKLSVDNQDK DLVYSLLLVL SGMLMDEKGK ECIVENIRII ISVLAQLVSY
PHMMVVRETA LQCFVAMSSF PHSKVYRMRP QVLQAAIKAL DDKKRAVRQE AVRCRQTWQS
SFA
//
