ID A0A453T2W8_AEGTS Unreviewed; 1094 AA.
AC A0A453T2W8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET7Gv21205100.6, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET7Gv21205100.6}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
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DR AlphaFoldDB; A0A453T2W8; -.
DR EnsemblPlants; AET7Gv21205100.6; AET7Gv21205100.6; AET7Gv21205100.
DR Gramene; AET7Gv21205100.6; AET7Gv21205100.6; AET7Gv21205100.
DR Proteomes; UP000015105; Chromosome 7D.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 48..316
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 707..1072
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1094 AA; 120850 MW; C966E9CEB82A38A8 CRC64;
MAKVPAGEWV PHVEAFVDVS RSPAQHSAGV DALAALVNKD KLTLFDLVSK MDMYLTTTDH
IVRSRGILLL GQIMSHISFK WLDVNAITTL SDFFISRLSD WQALRGALVG CLALLHRKSS
VGTIMVADVK RLVEAFIADV QVQSLAAADR KMCFEIFSWI LDHYPEAVKT MDDELLYWIC
QSIDEEKDPE CLKLSFHVVE VVMKLFPDPS GFADQFASDL FEILSKYFPV YFTHGAGDNL
GVTRDELSRA LMHAFCASPY FEPFAIPLLL DKLSSSLPLA KLDSLKYLDN CIHCYGADRM
VTHASAIWFK LKEVLFSLSS DQLLSSGSPK DAENNKNQIK SEAEHCLKTA VTYIHSPDRD
IFINLILLDE DIVNNIHSVT TEEKSIDSSL QALGSVVSIL AGSSTYLCTR VFQAHFKRLV
DILGNSAGFD SQHLSIANGS SPAAINYGAL YLSVQMLSSC REVAVASREG VPAEESWWLI
LEEKLDQIIH LFGKLLTIDC QPTQSAVRKE CVSCAVKGLL ILATIPEQCS LLLENAYEDI
LQMLTLVITS KYENAHFWRL SLKTLTSIGS SAVELHASKR EMVYNRIVVD KIICLAESCD
ASMPLNLRLE ACFEVGTASV NYMLRVARSL EETVIRNISQ VNGSIECADY VACLIDCYSS
RLLPWFFTSG GLNELALSFA LRLWDEIGDL VTLDRIISEG LLESLMMGMK LLVGVCTEEQ
QSLIVQKACG IVSSMLSLPV KALTHHLLSV DELVPAHSVQ DTALVCMLSS VIVGLWPQTP
VPEMMMMINL FSVFLLNGHI PAAHALASIF NKYLQNSEFS HEIKLDKILD VILGGCFSIV
LPSSNLKMSR SSAATSDNAD FSDSLPGSIG SKIDILCGLA WIGKGLLMRG DEKVKEISMF
LLKCLSSEAS LASAAADAFH VMMGDSEVCL NKKFHARIKF LYKQRFFSIL MPIFLSKIKE
TSELTTKLVI YRAFGHIISN APVSAVITEA HQILLVMVDI LAKLSVDNQD KDLVYSLLLV
LSGMLMDEKG KECIVENIRI IISVLAQLVS YPHMMVLKSF SYSVPLVRSA CLTTFFLSPV
GCSGDCLAMF CCHV
//
