ID A0A453YJP0_ANOAR Unreviewed; 1482 AA.
AC A0A453YJP0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AARA017890-PB.1};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA017890-PB.1, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA017890-PB.1}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA017890-PB.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; APCN01003502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblMetazoa; AARA017890-RB; AARA017890-PB; AARA017890.
DR VEuPathDB; VectorBase:AARA017890; -.
DR VEuPathDB; VectorBase:AARA21_004907; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13329; PH_RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR PANTHER; PTHR45872:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
SQ SEQUENCE 1482 AA; 160672 MW; 0C0ED454ED320AF1 CRC64;
MWFRTGSFPD DRFSVSTLKK RMRRKNKSTD DGQKQADSGE VPATGSTKAA TLDRREKSKD
RKGSADRAGS PSGPVTVGLM VIRPPPRTYK KSSSKSRLDG SKKAITMPIT DTRTTTGSAT
IKSSKSNTNL NINTLIKNKL NHNKHSPARF LAKLVDHHDG GGDGGTTPAG PYPLSPSKSI
SSSRAHLLHL SSGNLAPGHH KKYKLQKSKS RKALQQQQSK RSSIPSSTAA ESFTKKPEAN
TPHEDEDDRG TINSRKRVPS SAGEDEEEVD DLGDSTGNER GANTSLARQP SDRRQDLSGQ
LANTSGASDH LNSSSSDAYG YKQSADDDQF RENVKSKSAP VSVNRSESYK ERSQKKTRTT
RRKTSDPSLT KTADEQNEAS SLANNNYSSS STSSLPLALD SRSASMEAVG GGATTAVSSA
GPAGTVSGIN PTHSSPGGVG LPSSASTTSG GTGGGLHGGP VGSGGSGGPG GLNVPTAREW
IDSDDEGTVE PEADWSSNIA PEILSSIGDL EKKRQEVINE IYQTERNHVR TLRLLEGIFM
RPLQESGALP HDLLNLLFPH SLIHLKDLHT AFELKLKQRR SEHGNIVREI GDLLLTMFDG
QTGEELKEHA AHFCARQQIA LEALKERRKK DEQLQRILTK AESHKACRRL QLKDLLPTAL
QRLTKYPLLF DNLYNFTVRS TPKNEGEALA IRKSHESAKR ILDHVNQAVR TEEDMHKLAT
IQRKLDKSGL DKEAAVEFKN IDLTVRKLIH DGPLTMKKNP GVQLHGLLFE DIMVLLQKQD
DKYLVKYHSS PGLGGSESKY AEGRFNPITK IHLILVRQSA VDKNTFFLIN TNVSQMLELT
APSSTECKTW FKHISDAAEA YKSRTKGTHE YGEDSAGGGA GQPPKDSFET VTETQKIEQT
STPIERLERK DTQCRAVSSS AGHHHHHHHP AQPHHPHQQQ QQSPASQQAA GQPHHHHHHH
QSGGGRSDDS RLPSVPGAPD SSGANETEDN LENEEKEKFK RSSRRHGSRE ECNGGGRSSD
EEEEENGQQD DEDDERYTRG QSGRQGSSNN TRTITQQCSL VAPSEIHVSV SATLTAEPIL
TPAEQLRRYD QLIQKTLASK QRVVCDMFKV PDEHFQAIAD IAAQPEAPKE PTDLVLAAFA
YGQTLMEIVS ECMRVSESQQ VSAVSTAVCD DCSVLAAATG RTKQSNHHHH IPSPTTTKEP
LSEPTVPTIG GGPVPSVTAA AATISTATAG TFYNSAPAPI GVVAAQDQNV SITEDEDGYC
EIDEVRAAAV LLAENEKARK LTEAAAAAGG GVASGVDTLD DGGDVGRASQ SPESHIEINE
NYDSTQVKSK MMVSPQCPLG PEQCGKNRLL HASNLAPTVP CHLIASYVTG LNSQISQLLH
KISEKDMERE HLRRENQHLR ELLNAMHQER VLESQETNQD QQQNAPGDEQ TTSSSFSAIG
PEVAATQPPP SQQQQLQPTS PSSEEPSGTT VDNGSAPTVP TD
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