ID   A0A453YK07_ANOAR        Unreviewed;       899 AA.
AC   A0A453YK07;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial {ECO:0008006|Google:ProtNLM};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA017982-PA.1, ECO:0000313|Proteomes:UP000075840};
RN   [1] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AARA017982-PA.1}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA017982-PA.1};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
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DR   EMBL; APCN01001981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A453YK07; -.
DR   EnsemblMetazoa; AARA017982-RA; AARA017982-PA; AARA017982.
DR   VEuPathDB; VectorBase:AARA017982; -.
DR   VEuPathDB; VectorBase:AARA21_000324; -.
DR   OrthoDB; 1815533at2759; -.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR13847:SF291; PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL-LIKE PROTEIN; 1.
DR   PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
FT   DOMAIN          40..400
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          404..459
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          461..744
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          777..864
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   899 AA;  101150 MW;  E3D13AFADCCD3414 CRC64;
     MWNKLLKTVP GPRATGNHTC GTVVRLGSSE ATPQVSRQAR VVVAGAGLLG NSVAYHLADN
     GWSNVLVLDQ SKVGSGTSHF GSGTIGLFKP TPERNIVVES LKLYQRLQDQ GHDIGLRRCG
     SLNLAQTHDR VIALQRRAAY ILPTGMAAEL IDSETARKLH PFLYTDDLQG AVYVPDDCIA
     DPAAVVQVLA SEAKRKGVKY FEGCQVKYIN TKNERVFSVE TDVGTITCEY FVNCSGMWAR
     ELGLKCKPPV RVPAYPAQHY YALTPTLDLP TDDDNLLPCI RDYDSNLYAR QYDQSLLVGW
     FEKDAKPAFE ETKDIPKAWQ DHLQDDPDHC AALWEKAVDR LPVLRDLRMP TVRNSPDNFT
     PDGRFIFGES AEVKNYFVAC GMNGNPLQGS GGVGKALAEW IVSGTPTIDM LPFNVQRFLD
     LHNNRQYLQQ RIREVVGRQY AILYPNQAEY KFARKLRCSP LYSVLEARGA VFGTKMGYER
     ALYFDADYRR GDPLPTLPEG SFYKPKFFQH MEKEYQACAQ HVGIIDISSF SKIEIKPGIQ
     SDAAGSGGNA VLSYLQYMCA NDVNIAVGHI VHTGMLNERG GYENDCMLIR QTEESYFMIS
     PSSQQTRIYE WMSRNLPTDA SVQLNDVTSM YTVINVVGPK STLLMSELSN SDVRLAPFSY
     RKLNIGYASD VMIMSFTHTG MPGYCLYVPS EYALHVYDRL ITRGRDYGAR DVGTLTQRLL
     RIDKFIPFWG DELTSMTTPF EAGVFYSVRL DISQLKKKEN FIGRQALERQ KRDGLRKRLV
     LFHVEDIDID KDVWPWGGEP LYRNNEFCGT VTSAGYGFAS EKLVCLGYIS RPDSNAVRTI
     TTEFIMDKDA VYHIDIAGKR FRLTQHIHPK AAMASANERQ DMSKSYRPTV VKEKKQQKS
//