ID   A0A453YK59_ANOAR        Unreviewed;      2190 AA.
AC   A0A453YK59;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AARA018047-PA.1};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA018047-PA.1, ECO:0000313|Proteomes:UP000075840};
RN   [1] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AARA018047-PA.1}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA018047-PA.1};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; APCN01003167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; AARA018047-RA; AARA018047-PA; AARA018047.
DR   VEuPathDB; VectorBase:AARA018047; -.
DR   VEuPathDB; VectorBase:AARA21_013247; -.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   CDD; cd21223; CH_ASPM_rpt1; 1.
DR   Gene3D; 1.20.5.190; -; 4.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR031549; ASH.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR   PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR   Pfam; PF15780; ASH; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00612; IQ; 5.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 23.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 8.
PE   4: Predicted;
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
SQ   SEQUENCE   2190 AA;  254900 MW;  356EE5622F54723A CRC64;
     MSAFEVSCTP PRAVAKPRTN ESREPTLVLL GPFTPKATVV FEGVPVGKSA RRLLIVRNTN
     KTLVQVNLTR VPDPGCGLWF EWTTADVEAG AEKTLEVVWN PQQLLVGKDV LVLTDSIGNK
     KDVQFILKTV EPKSTASRKP VAKSFAVPKK LKLKSPSPPK VKLKRNVLPK KTKTSPGKPG
     WSVPTITVGS RMGTIASKVT TAMYGPGAGD GSFDMMDEYG AANSGTMRKE GDKNTTDKEN
     VNPTSPLVIG ARLDAKQFLS PLSVNDSYVK CVENQPTPDY FMKGKGRRGL IDHSVRKNLE
     VSPKAPTAEM VTESDAMDDK SRQKTTALTP QDRNTRFDPS CFSTVTKPLP VDKTFLKPFI
     ASPTMVDSSL VQQQSDENLQ RHLTFSLEHE KGDTEEHELE TNQKDEMPVH GEHPVHGEHP
     EPATDKTHTV AHDSSPHLTS IAEEIVPELG ITFERRHDRR NGSVSDDTEL LASLRTQQTF
     IVSAEQSSRS ASVENIVRNV TVTIKDSVSR SSLPNLLDKS SSSNSSSTNK SHHLEEDEGD
     KIFREHEIRA QSSRFNLHEV GRFSDEMVVP STGCKRSIES VGDGKELKLE PFELTISPPK
     RRCRLTSSSS AIIAQALQSV TKTETQMSIS STFRKPIGYK STTPSTRSVT LSTSRSLSLK
     RTAVPCSLPP KSEEKRVFLY DSDRHLKTLI NPDPFAATTT CNPFLTVTMY LDERAFEQYE
     RQMKKWLNAL VTIPADLDTE PNKPLDVGKL FDEVKSKELT LAPTKELISS KYYKTRLNHL
     RSAGIALYTS EEIAMPLRKV AAQIEKQLLS LRTDRNLHLD LVLQRSILEL LLCFNPLWLR
     LGLEVVFGEQ IELQSNRDIV GLSTFIIHRL FRDRYLEARN SKAYNLSRAY AEHMRKFTLR
     MVLFLLLFLD TAKRRKLIKH NPCLFVRNAP HKETKEILIR FASQLVSGIG DITKHMKRVG
     YVLSHKQSFL DEYNYAFENL AVDLRDGVRL TRVMEIILLR DDLSASLRVP PISRLQKIHN
     INLALVALEQ ADYKIAGNVT AKDICDGHRE QTMSLLWQIV YKFRAPKFNA AAIVLQRWWR
     MNWLKVTISR RIEEKRALRR EAAARTIQAA VRGYCVRVWY EAHRRQKLRA IVTIQRFTRR
     YLAQKLAARR FSAILRIQQW WRTVRQMRQA RERFLLCRKS AIVLQTSYRR YALGRKLLAA
     ATLIGQIRAE AKHRHLQATI IQRSIKSYVI HRRLHATVNG MVAFIRRKRL QNRSAAKIQA
     YQRMRIVRKE YLRSRSAAIC IQRRWRECME ARRLRSRFLL MRASAIRLQQ QYRGWRQMRQ
     DRHTYAHARN LIVQVQRRWR GTLAMRKERA NYRTLRRVAI NVQRRFRARQ AMQSEVERYR
     TLCKATVTLQ QRFRANKAMM EQRQQYNSLR VATLCVQRRF RAQLSMRAAR ASYAKVRCAI
     LTIQSQYRAT LAMRQARDRF VTLRRCTITV QARFRAILAG RAAKQRYESI RKATLHIQRK
     WRATLEMRQV RSHYRRQCNA ALTLQRLWRG VLLQRKFRHD YLLYRDAATV LQRRYRALVQ
     GRMVRRETQH CRWAAVTIQR RLRATLQMNR DRNAFLQLRQ SVLVVQRRFR ANRACRVQRV
     QYAALKRSAI TVSHRWAATL HMRQQRSEFL RLKSATVVMQ RRYRAQRAKQ QAVQQYERVR
     AAIVLLQRKY RAQRAMEKCR GRFLNLKSAS IVVQEFYRGY RNMRHDRAAF IRLRESVLAI
     QRRFRGKLLT RQTVVEYERK RKAAVTLQRW FRGHRAMVME RKRFTALKHA ATVIQARYRA
     RRAMLHDAAQ YGRIYRAVTT IQIHWKATLS MRRERVRYQQ TLRAVRTIQI HYRAYRERLI
     DEANYRIYRS AVIVVQRRYR EKLQTRCESL RFEQIRRTVR GLQTYGRGVL ARRAFLALLT
     PEYLERKRQQ KAALRIQAWW RGAYHRKRYQ TMQMRKIAQQ MVASRMAARR DPTIRLSNVS
     RLCLRFLKTR FSSSEAIGIL KRLERMSRLV PHLLMEDAVF LSVFCYNMMA QAIRSEVDKI
     LIEICARIIL NLARFRDTKE QAFQEDGLVT VSQMLLRWCD KDCGIFSTLC TLLWVLAHDN
     KKKNAIRRYM ISKDAIYMLR ETKKLVQRKE KMRKNVQRPV GCLVAPNPQL MRTVPSLEPD
     FGVNRSKPYV FYSSVFGFER VLQMLEVDLS
//