GenomeNet

Database: UniProt
Entry: A0A453Z3J7_ANOQN
LinkDB: A0A453Z3J7_ANOQN
Original site: A0A453Z3J7_ANOQN 
ID   A0A453Z3J7_ANOQN        Unreviewed;      2858 AA.
AC   A0A453Z3J7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles quadriannulatus (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA017190-PA, ECO:0000313|Proteomes:UP000076407};
RN   [1] {ECO:0000313|Proteomes:UP000076407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AQUA017190-PA}
RP   IDENTIFICATION.
RC   STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA017190-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   STRING; 34691.A0A453Z3J7; -.
DR   EnsemblMetazoa; AQUA017190-RA; AQUA017190-PA; AQUA017190.
DR   VEuPathDB; VectorBase:AQUA017190; -.
DR   Proteomes; UP000076407; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd01221; PH_ephexin; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11793; SH3_ephexin1_like; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047271; Ephexin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR047270; PH_ephexin.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12845:SF5; EPHEXIN, ISOFORM D; 1.
DR   PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          2360..2547
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          2723..2784
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          1..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          547..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          873..895
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          932..1059
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1106..1141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1167..1186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1252..1280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1357..1489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1606..1645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1657..1795
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1822..2014
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2029..2107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2124..2184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2198..2226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2272..2322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2833..2858
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..185
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..370
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..509
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        547..563
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..599
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        606..633
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        640..656
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        665..686
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        742..777
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        784..799
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        952..1013
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1029..1044
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1045..1059
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1168..1185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1252..1269
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1357..1372
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1396..1424
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1444..1479
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1606..1622
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1673..1688
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1705..1728
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1753..1767
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1768..1782
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1826..1869
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1912..1964
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1995..2014
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2029..2051
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2089..2107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2128..2146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2198..2212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2858 AA;  310261 MW;  E71153E059538CE0 CRC64;
     MMHIKSSPTT PLVAGEKRPK KESSQPQDTR KVSSFIQRFY LFGNSPSTPH GAEAEPEAPK
     VKKTKVSNQQ TTGDTQPNSK SAATARPGSS PSTDGTVSSS SEPSEELNPV QYPSYSVQRL
     RQFWNNRLLS NQQPTGSSID TLVRKAKSAT IGAPTGAAAR TVLRKSPSPK ATTRFQRNGS
     ITRSGRRRFG TLDCSESVRS GLDVNVQRSA QPPKRSSHAA LLSPDREAQR TLVEKRPCVG
     STPVTAGPSA RESFPLAVST PNGSQIHWAR RTELLGIRAL TQEEKKQCAK MPLRVENYVN
     SYIDVDIQSV GGQDEPARNV SVPVQEPPKD VLEKLPPIPN TSTPVTTPAR QPSTSSLGRK
     GNTPTRKISF MNNISPYNRK LLACNGTKVA ALTSKFNQMI QQDAGLLAQV QKRGGYLHKC
     GNVAYKVIED PGSDGVYGFT STGRMSSARS SLRKKHSNAS ATSGGGSTAA AATATATAAT
     ATSAGTAGNR TDESSDEISS SASSKNSSLR KTGLRKRPSL RKNIYRRPEW ETGRSSLGVR
     KVLEMFEPNL HHGRGKRTES GDTGKPPPGR SKPKVPDKSE QVLQKTKDFK SKKVVGEVVE
     KSNRGALNEQ VEEVRGDVAT ARSADEHVVD GSRQETNESS PVSKEAKSKD VVVSPKEAKK
     GSSGITSKLH KNSPREASNA NVPSKGENLK PTEVLSDGDN SVGELHPSYN WKDGTYDQID
     LEEPTNGKEI SAVSKPNEMI SSQKVLKEKE KSKSAVSKIQ ERLTFRSSKK VTVENTAPRK
     EPSEGFANRS DHDLGEDQAA YSSAEKGSKQ GTEEPSPYHA VKVSTGANQE LIEVLSDGES
     SFGELHPSYN WTDGTYDRKY VEQAAQINAA YSSVEKGSKK VTEEPSPYHS VKASTGANQE
     LIGVLSDGDS SFGELHPSYS WMDGTYDQID LEEPTNGKEI AIASATTEMS ASQKDPKEKE
     KGKSAVSKIQ ERLTFRSSKK VAVENPAPRK EPSEEVANLS DDDFGENHAE YSFLEKGSKQ
     VTEEPSPHDA VQPDNSSQTE TVVTSPKEGK EKKRSKSTVS KIYERLTFRS SKKMAAPSER
     SDEVVIIREA EDANRKASGL RRSFVSSIEI PSIHPDERAV ASPSPEASRE ESTEKDSSEQ
     KILEAISAVS QRIDNLSKSF SDLTLTDDEN TQAKRTADAE QEEDVQQVRP NASFLFRGMG
     SAGSRAGLDS KHASQHNIVE AVNTVVINKS LSMDDHHFPC ARGETGRMSL NERSRAQRGL
     EDDYEPVTQP EEKLPSAAGS KFCSTPSITI DLSELTSKIE SFVHKSKRES DNIYQSIPIK
     PHVTDNAALL HQPEDAISVN SYESFENYES IEHELLSSTR KQNAEKASGE EDTYEICSPP
     PELPPAREDS RNDLTLPQPK RNLSSSPKTL PKHLQVTYQS NYERIKYSKI PPRPPKPEEV
     PLPPRNSSTA STGATSTAAN VTLEASTSHS SSTEQASSGA GGDLLDKSPH RQERIYEENI
     YDTIRSADGV DYDDPACGSA ELDPTQTTQP GGIRVGLSSR ARQQPSPPAD NVSLVSSNCY
     ESIGLRLEYE RSMMLARRNL AGGSTTTLAS DQITNSLYGV TAGLASLTPP SERGSDTSNS
     ADWTDISDED EAGERADVTT AMATGGSKRP NFIVVRERKR THQTPLRSRK LARISHPKID
     DDSDHHYESL YSIGSNDGRH QHQHDSNYTT LPSHAEGSPL SGNGTSGVNF HEHRAGGGGG
     DASAAMLLPP DDEFDSFDSD DTDYEDEDDD RNRARTDSGV DIRNAKLPDP PPSSSQVYVL
     VQKIKNLGTL SEIAKSFHKL SKKKGTKGAT TTTGAGGGTY ENTVLGSKHA GTKTGSKGMS
     SSTSSKSFKL PPLPLVGGGG GVPKPPPEDY EGAAVGSPHS GTHPVPPGSS LLLPASSPSL
     SSASTTANRA AGATPLISSP VPEQSSSAGV RSTSESSNVS GNVPKAPGSA GFSPADGATR
     KKSKSTKSLR SKLRKSLVSD STSLNIGSSF NGSRSTFYVT SADVDSGIFN GSDGCLNPSA
     SSVSQSQEMP TKPVEDNRRK SIASATGTTG HGRPTIPPPP PPAEAGKRTA ASSSVSPLLA
     ASNSKSVSKK LGATSWYAEC GVFKQPHSFG TGSDQSLSNG KGDGSISPRS SLPPKDGGPT
     GVGPGGVGGG GSAGDRTLTS NGHTSASSWY ADIYQTSGAS VASSSESSGV STGGEGGPGD
     DHSHSMFVNE PLYQIYNAAK LESITRDIDA EISGRSEAEL YDDGYEKIAE RNRRRKTGGA
     GEQEGGEEGD EGGCSSSSGS SSTDGDDRGD DSAMHLRKPS RPTALELIEP HIGKLRTLWC
     EVPEVRNSEI LATLTPTEKR LQEAKFEILT SEASYLKSLN LLRTHFVNHP AFRDTRILSS
     SERKTLFSSI IPVQECSDRL LCDLENCWQD NIMLLGLSHS IYKHAEKHFH VYVTYCEHQA
     KIDRTLKALK ANKPEFARTL AALEADPVCC SLSLSSFLML PMQRITRMRL LLDAVLQRCH
     PDDDDEFGSW ESTFVLINRI LTQCNDAAHR SEQLYEMELL SRQIEFPTNV RPLAIVPCGI
     GAAPSTMHRK LEKRGDLVHV LWRGDDAKLT FGKKFSKSNV YAFLFTDLLV LTKKKSDESY
     LVIDYCQRAL LTVSSGDIVT GLPAKEMQTI GKNLIIMTLL ENHEGKTIEM ILSCPSETER
     ERWLMVTEPL ASENPDEKIY EQWDCPQVIA VHPYQALQPD ELDLDIKDVV NVHRKMADGW
     YEGERIRDGA VGWFPSNYTK EIPSAHIRAK HIKQRHLLLT YTSKYIDTAT KAHHHYHNYY
     HQPQHQQQHY HQLHHKQQHL QHQQQYHHHH HLQQQSKK
//
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