ID A0A453Z3J7_ANOQN Unreviewed; 2858 AA.
AC A0A453Z3J7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles quadriannulatus (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34691 {ECO:0000313|EnsemblMetazoa:AQUA017190-PA, ECO:0000313|Proteomes:UP000076407};
RN [1] {ECO:0000313|Proteomes:UP000076407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SANGQUA {ECO:0000313|Proteomes:UP000076407};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles quadriannulatus QUAD4_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AQUA017190-PA}
RP IDENTIFICATION.
RC STRAIN=SANGQUA {ECO:0000313|EnsemblMetazoa:AQUA017190-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 34691.A0A453Z3J7; -.
DR EnsemblMetazoa; AQUA017190-RA; AQUA017190-PA; AQUA017190.
DR VEuPathDB; VectorBase:AQUA017190; -.
DR Proteomes; UP000076407; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11793; SH3_ephexin1_like; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF5; EPHEXIN, ISOFORM D; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 2360..2547
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 2723..2784
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1357..1489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1606..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1657..1795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1822..2014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2029..2107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2124..2184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2198..2226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2272..2322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2833..2858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..799
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1606..1622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1705..1728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1753..1767
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1768..1782
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1826..1869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1995..2014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2029..2051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2089..2107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2128..2146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2198..2212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2858 AA; 310261 MW; E71153E059538CE0 CRC64;
MMHIKSSPTT PLVAGEKRPK KESSQPQDTR KVSSFIQRFY LFGNSPSTPH GAEAEPEAPK
VKKTKVSNQQ TTGDTQPNSK SAATARPGSS PSTDGTVSSS SEPSEELNPV QYPSYSVQRL
RQFWNNRLLS NQQPTGSSID TLVRKAKSAT IGAPTGAAAR TVLRKSPSPK ATTRFQRNGS
ITRSGRRRFG TLDCSESVRS GLDVNVQRSA QPPKRSSHAA LLSPDREAQR TLVEKRPCVG
STPVTAGPSA RESFPLAVST PNGSQIHWAR RTELLGIRAL TQEEKKQCAK MPLRVENYVN
SYIDVDIQSV GGQDEPARNV SVPVQEPPKD VLEKLPPIPN TSTPVTTPAR QPSTSSLGRK
GNTPTRKISF MNNISPYNRK LLACNGTKVA ALTSKFNQMI QQDAGLLAQV QKRGGYLHKC
GNVAYKVIED PGSDGVYGFT STGRMSSARS SLRKKHSNAS ATSGGGSTAA AATATATAAT
ATSAGTAGNR TDESSDEISS SASSKNSSLR KTGLRKRPSL RKNIYRRPEW ETGRSSLGVR
KVLEMFEPNL HHGRGKRTES GDTGKPPPGR SKPKVPDKSE QVLQKTKDFK SKKVVGEVVE
KSNRGALNEQ VEEVRGDVAT ARSADEHVVD GSRQETNESS PVSKEAKSKD VVVSPKEAKK
GSSGITSKLH KNSPREASNA NVPSKGENLK PTEVLSDGDN SVGELHPSYN WKDGTYDQID
LEEPTNGKEI SAVSKPNEMI SSQKVLKEKE KSKSAVSKIQ ERLTFRSSKK VTVENTAPRK
EPSEGFANRS DHDLGEDQAA YSSAEKGSKQ GTEEPSPYHA VKVSTGANQE LIEVLSDGES
SFGELHPSYN WTDGTYDRKY VEQAAQINAA YSSVEKGSKK VTEEPSPYHS VKASTGANQE
LIGVLSDGDS SFGELHPSYS WMDGTYDQID LEEPTNGKEI AIASATTEMS ASQKDPKEKE
KGKSAVSKIQ ERLTFRSSKK VAVENPAPRK EPSEEVANLS DDDFGENHAE YSFLEKGSKQ
VTEEPSPHDA VQPDNSSQTE TVVTSPKEGK EKKRSKSTVS KIYERLTFRS SKKMAAPSER
SDEVVIIREA EDANRKASGL RRSFVSSIEI PSIHPDERAV ASPSPEASRE ESTEKDSSEQ
KILEAISAVS QRIDNLSKSF SDLTLTDDEN TQAKRTADAE QEEDVQQVRP NASFLFRGMG
SAGSRAGLDS KHASQHNIVE AVNTVVINKS LSMDDHHFPC ARGETGRMSL NERSRAQRGL
EDDYEPVTQP EEKLPSAAGS KFCSTPSITI DLSELTSKIE SFVHKSKRES DNIYQSIPIK
PHVTDNAALL HQPEDAISVN SYESFENYES IEHELLSSTR KQNAEKASGE EDTYEICSPP
PELPPAREDS RNDLTLPQPK RNLSSSPKTL PKHLQVTYQS NYERIKYSKI PPRPPKPEEV
PLPPRNSSTA STGATSTAAN VTLEASTSHS SSTEQASSGA GGDLLDKSPH RQERIYEENI
YDTIRSADGV DYDDPACGSA ELDPTQTTQP GGIRVGLSSR ARQQPSPPAD NVSLVSSNCY
ESIGLRLEYE RSMMLARRNL AGGSTTTLAS DQITNSLYGV TAGLASLTPP SERGSDTSNS
ADWTDISDED EAGERADVTT AMATGGSKRP NFIVVRERKR THQTPLRSRK LARISHPKID
DDSDHHYESL YSIGSNDGRH QHQHDSNYTT LPSHAEGSPL SGNGTSGVNF HEHRAGGGGG
DASAAMLLPP DDEFDSFDSD DTDYEDEDDD RNRARTDSGV DIRNAKLPDP PPSSSQVYVL
VQKIKNLGTL SEIAKSFHKL SKKKGTKGAT TTTGAGGGTY ENTVLGSKHA GTKTGSKGMS
SSTSSKSFKL PPLPLVGGGG GVPKPPPEDY EGAAVGSPHS GTHPVPPGSS LLLPASSPSL
SSASTTANRA AGATPLISSP VPEQSSSAGV RSTSESSNVS GNVPKAPGSA GFSPADGATR
KKSKSTKSLR SKLRKSLVSD STSLNIGSSF NGSRSTFYVT SADVDSGIFN GSDGCLNPSA
SSVSQSQEMP TKPVEDNRRK SIASATGTTG HGRPTIPPPP PPAEAGKRTA ASSSVSPLLA
ASNSKSVSKK LGATSWYAEC GVFKQPHSFG TGSDQSLSNG KGDGSISPRS SLPPKDGGPT
GVGPGGVGGG GSAGDRTLTS NGHTSASSWY ADIYQTSGAS VASSSESSGV STGGEGGPGD
DHSHSMFVNE PLYQIYNAAK LESITRDIDA EISGRSEAEL YDDGYEKIAE RNRRRKTGGA
GEQEGGEEGD EGGCSSSSGS SSTDGDDRGD DSAMHLRKPS RPTALELIEP HIGKLRTLWC
EVPEVRNSEI LATLTPTEKR LQEAKFEILT SEASYLKSLN LLRTHFVNHP AFRDTRILSS
SERKTLFSSI IPVQECSDRL LCDLENCWQD NIMLLGLSHS IYKHAEKHFH VYVTYCEHQA
KIDRTLKALK ANKPEFARTL AALEADPVCC SLSLSSFLML PMQRITRMRL LLDAVLQRCH
PDDDDEFGSW ESTFVLINRI LTQCNDAAHR SEQLYEMELL SRQIEFPTNV RPLAIVPCGI
GAAPSTMHRK LEKRGDLVHV LWRGDDAKLT FGKKFSKSNV YAFLFTDLLV LTKKKSDESY
LVIDYCQRAL LTVSSGDIVT GLPAKEMQTI GKNLIIMTLL ENHEGKTIEM ILSCPSETER
ERWLMVTEPL ASENPDEKIY EQWDCPQVIA VHPYQALQPD ELDLDIKDVV NVHRKMADGW
YEGERIRDGA VGWFPSNYTK EIPSAHIRAK HIKQRHLLLT YTSKYIDTAT KAHHHYHNYY
HQPQHQQQHY HQLHHKQQHL QHQQQYHHHH HLQQQSKK
//