ID A0A455AB58_PHYMC Unreviewed; 550 AA.
AC A0A455AB58;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Transmembrane protein 145 isoform X4 {ECO:0000313|RefSeq:XP_028333270.1};
GN Name=TMEM145 {ECO:0000313|RefSeq:XP_028333270.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028333270.1};
RN [1] {ECO:0000313|RefSeq:XP_028333270.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028333270.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_028333270.1; XM_028477469.2.
DR AlphaFoldDB; A0A455AB58; -.
DR Proteomes; UP000248484; Chromosome 17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR PANTHER; PTHR23252:SF24; TRANSMEMBRANE PROTEIN 145; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..550
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019742872"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..398
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
FT REGION 492..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..516
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 61214 MW; 612083C2E5E0A93E CRC64;
MEPPRAPALR RLLLPPLLLL LLPLPPRARA KYVRGNLSSK EDWVFLTRFC FLSDYGRLDF
RFRYPEAKCC QNILLYFDDP SQWPAVYKAG DKDCLAKESV IRPENNQVIN LTTQYAWSGC
QVVSEEGMRY LSCSSGRSFR SGDGLQLEYE MVLTNGKSFW TRHFSADEFG ILETDLTFLL
IFILIFFLSC YFGYLLKGRQ LLHTTYKMFM AAAGVEVLSL LFFCIYWGQY ATDGIGNESL
KILAKLLFSS SFLIFLLMLI LLGKGFTVTR GRISHSGSVK LSVYMTLYTL THVVLVIYEA
EFFDPGQVLY TYESPAGYGL IGLQVAAYVW FCYAVLISLR HFPEKQPFYV PFFAAYTLWF
FAVPVMALIA NFGIPKWARE KIVNGIQLGI HLYAHGVFLI MTRPSAANKN FPYHVRTSQI
ASAGAPGPGG SQSADKAFPQ HVYGNVTFIS DSVPNFTELF SIPPPTSCAG KQVEETAVAA
AVAPRGRVVT MAEPGAASPP PPARFPKAAD PSWDGPTPPY QPLVPQTAAP HTGFTEYFSM
HTAGGTAPPV
//
