ID A0A455ACI7_PHYMC Unreviewed; 518 AA.
AC A0A455ACI7;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Nuclear receptor subfamily 4 group A member 2 {ECO:0000256|ARBA:ARBA00019630};
GN Name=NR4A2 {ECO:0000313|RefSeq:XP_028333950.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028333950.1};
RN [1] {ECO:0000313|RefSeq:XP_028333950.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028333950.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction
CC with NCOR2 increases in the absence of PITX3. Interacts with PER2.
CC {ECO:0000256|ARBA:ARBA00025857}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_028333950.1; XM_028478149.2.
DR AlphaFoldDB; A0A455ACI7; -.
DR Ensembl; ENSPCTT00005011752; ENSPCTP00005010611; ENSPCTG00005007489.
DR Proteomes; UP000248484; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06969; NR_DBD_NGFI-B; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; NR4A1-3.
DR InterPro; IPR003073; NR4A2.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24085; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24085:SF0; NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR01287; NURRNUCRCPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_028333950.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 271..346
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 371..518
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 348..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 57671 MW; 2A27C6F192AE7E57 CRC64;
MNEERHGELL TMPCVQAQYG SSPQGASPAS QSYSYHSSGE YSSDFLTPEF VKFSMDLTNT
EITATTSLPS FSTFMDNYST GYDVKPPCLY QMPLSGQQSS IKVEDIQMHN YQQHSHLPPQ
SEEMMPHSGS VYYKPSSPPT PTTPGFQVQH SPMWDDPGSL HNFHQNYVAT THMIEQRKTP
VSRLSLFSFK QSPPGTPVSS CQMRFDGPLH VPMNPEPASS HHVVDGQTFA VPNPIRKPAS
MGFPGLQIGH ASQLLDTQVP SPPSRGSPSN EGLCAVCGDN AACQHYGVRT CEGCKGFFKR
TVQKNAKYVC LANKNCPVDK RRRNRCQYCR FQKCLAVGMV KEVVRTDSLK GRRGRLPSKP
KSPQEPSPPS PPVSLISALV RAHVDSNPAM TSLDYSRFQA NPDYQMSGDD TQHIQQFYDL
LTGSMEIIRG WAEKIPGFAD LPKADQDLLF ESAFLELFVL RLAYRSNPVE EYEHRHFCLL
LHCCPGYGHR ETRSQGAQES GGAAKQDCKL SQRPCDFQ
//
