ID A0A455ADD4_PHYMC Unreviewed; 973 AA.
AC A0A455ADD4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Integrin alpha-9 isoform X4 {ECO:0000313|RefSeq:XP_028334305.1};
GN Name=ITGA9 {ECO:0000313|RefSeq:XP_028334305.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028334305.1};
RN [1] {ECO:0000313|RefSeq:XP_028334305.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028334305.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_028334305.1; XM_028478504.1.
DR AlphaFoldDB; A0A455ADD4; -.
DR Proteomes; UP000248484; Chromosome 18.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF69; INTEGRIN ALPHA-9; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 30..973
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5019616527"
FT REPEAT 35..96
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 290..349
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 351..408
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 413..474
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 459..618
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 620..764
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 772..952
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 973 AA; 106809 MW; D414EFC188A31E91 CRC64;
MGGPAARRGA GGLHALLLAL VAAGSPAGAY NLDPQRPVRF QGPAGSFFGY AVLEHFHDNT
RWVLVGAPKA DSKYSTSVKS PGAVFKCRVH TNPDRRCTEL DMARGKNRGM PCGKTCREDR
DDEWMGVSLA RQPKADGRVL ACAHRWKNIY YETDHILPHG FCYIIPSNLQ AQGRTLIPCY
EEYKKKYGEE HGSCQAGIAG FFTEELVVMG APGSFYWAGT VKVLNLTDNT YFKLNDEVIM
NRRYTYLGYA VTAGHFSHVS TTDVVGGAPQ DEGIGKVYIF RADRRSGTLI KIFQASGKKM
GSYFGSSLCA VDLNMDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE QLALNGDGAY
NAHFGESIAS LGDLDDDGFP DVAIGAPKED DFSGAVYIYH GDAGGMVPQY SMKLSGRKIS
PVLRMFGQSI SGGIDMDGNG YPDVTIGAFM SDSVVLLRAR PVITVDVSIF LPTSINITAP
QCHDGQQPVN CLNVTACFSF HGKHVPGKIG LNYVLTADMA KKEKSQLPRV YFVLLGESVG
QVSEKLQLVH LEATCHHYVA HVKRRVQDVI SPIVFEAAYS LGEHVMGEEE RELPALTPVL
RWKKGQKIAQ KNQTVFERNC RSEDCAADLQ LQGHLLLSSV DDRTPYLAMG AVKNISLNVS
ISNLGDDAYD ANVSFNVSRE LFFINMWQKE EMGISCELLE SDFLKCSVGF PFMRSKSKYE
FSVIFDTSHL SGEEEVLCFI VTAQSGNMER SESLHDNILT LAVPLMHEVD TSITGIMSPT
SFVYGESVDA SNFIQLEDLE CHFQPLNVTL QVYNTGPSTL PGSSVSISFP SRLSPGGAEM
FHVQEMVVGQ EKGNCSFQKN PTPCIIPQEP ENIFHTIFAF FTKSGRKVLD CEKPGISCLT
MHCNLSALAK EESRTIDIYM LLNTEILKKD SSSVIQFMTR AKVKVDPALR VVEVASGNSE
EMTDRLMSEN PSL
//
