ID   A0A455AG09_PHYMC        Unreviewed;      1872 AA.
AC   A0A455AG09;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2023, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Desmoplakin {ECO:0000313|RefSeq:XP_028334688.2};
GN   Name=DSP {ECO:0000313|RefSeq:XP_028334688.2};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028334688.2};
RN   [1] {ECO:0000313|RefSeq:XP_028334688.2}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028334688.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_028334688.2; XM_028478887.2.
DR   STRING; 9755.ENSPCTP00005011474; -.
DR   KEGG; pcad:102986031; -.
DR   InParanoid; A0A455AG09; -.
DR   OrthoDB; 4322299at2759; -.
DR   Proteomes; UP000248484; Chromosome 18.
DR   GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.1060; -; 1.
DR   Gene3D; 1.20.58.60; -; 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR041615; Desmoplakin_SH3.
DR   InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR   InterPro; IPR043197; Plakin.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   PANTHER; PTHR23169:SF26; DESMOPLAKIN; 1.
DR   PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR   Pfam; PF17902; SH3_10; 1.
DR   Pfam; PF18373; Spectrin_2; 1.
DR   Pfam; PF21019; Spectrin_3; 1.
DR   SMART; SM00150; SPEC; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          468..525
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          1667..1692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1033..1279
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1312..1367
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1394..1442
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1769..1869
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1872 AA;  218317 MW;  32CC145516050924 CRC64;
     MSCNGGSDPR INTLGRMTRA ESGPDLRYEM TCGGGGGGGG GSSGGGGTSR MYYSRRCTVT
     DQNSDGYCQT GTMSRQNQNT IQELLQNCSD CLMRAELIVQ PELKYGDGIQ LAQSRELDEC
     FAQANDHMEI TDSLIREMRQ MGQPCDAYQK RLLQLQEQMR ALYKAISVPR VRRASSKGGG
     GYTCQSGSGG DEFTKRLTSE CLGWMQKQRA EMDMITWGVD LASVEQHISS HRTIHNAIGE
     YRWQLDKIKA DLREKSAIYQ LEEEYENLLK TSFERMDHLR QLQSIIQAAS QEIMWINDCE
     EEELLYDWSD RNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLSQ HPASDKIEAY
     MDTLQTQWSW ILQITKCIDV HLKENAAYFQ FFEEAQSTEA YLKGLQDCVR KKYLCDKSMP
     LQHLLEQIKV LEKEWETILE NRRQVQSLVN KSKRIVQLKP RNPDYRSNKL IIVRALCDYK
     QDQKIVHKGD ECILKDNNER SKWLVTGPGG VDMLVPSVGL IIPPPNPLAV DLSSKIEQYY
     EAILALWNQL YINMKSLVSW HYCMIDIEKI KAMTIAKLKT MRLEDYTKTI SDLELRYQDF
     IRDSQGSEMF GDDDKRKIQT QFTDAQKHYQ TLVVQLPSYP QHQTVTATEI THLGSCHNKV
     IETNRENDKQ ETWLLMELQK IRRQMELCES GMTLKNVLLA DQGSSQHITA KINELKGLQN
     DSQTFAQVLN QLKDMLANFR GSEKYCYLQN EVFGLFQKLE NINGVTDGYL NSLCMVRTLL
     QAILQTEDML KVYEARLTEE ETVCLDLDKV EAYRCGLKKI KNDLNLKKSL LATMKTELQK
     AQQIYSQTSQ QYPLYDLDLG KFSEKVTQLT DRWQRIDKQI DYRLWDLEKQ IKQLRNYRDN
     YQTFCKWLCD AKRCQDNLES MKFGDSNMVM RFLNEQKNLH SDISGKRDKS EEVQKIAELC
     ANSIKDYELH LASYASGLET LLSIPVKRTI VQSPSAMILQ EAADMHARYI ELLTRSGDYY
     RFLSEMLKSL EDLKLKNTKI EVLEEELRLA RDANSENCSK NKLLDQNLQK YQAECSQFKA
     KLVSLEELKR QAELDGKSAK QNLDKCYSQI KELNEKITRL TYEIEHEKRS RKTVEDRFDQ
     QKNDYDQLQK ARQSEKESLG WQKIESEKAI KEKEFEIERL RALLQEESTR KREYENELAK
     VRNQYSEEMS NLRNKYETEI NITKTTIKEI SMQKEDDSKN LRNQLDRFSK ENRDLKDEIV
     RLTNSILQIT EERRRAEEAA LQQKACGSEM LQEKQHLEME LKQVIQQRSE DNARHKQSLE
     EAAKTIQDKN QEIERLKAEF QEEAKRRREY ENELAKVRNN YDEELISLKN QFETEITITK
     TTIQQLTLQK EEDTSGYRAQ IDNLTRENRS LSEEVTKLKN ALAQTTENLR RVEESVQQQK
     AAGSEMSQRK QQLEVELTQV MQVRMEESTR YRQSLDDAAK TIQDRNTEIE RLKQLTETEA
     KQRKCLEDEN AKLQRAQCEL QKAYSSAMET VSKLKAQEQE LMCLRLDYER VAQERTLREQ
     DAARLQSSLK ELQPQRQRLQ EELTRLKRAA SEDSFRRKKL DEELETLRRA RKEQAVKVTS
     LTQQLEQASV ARKRSEDALD GHLREKQRAQ DELRRLASDV EALRRQLSQE QESAREAQAR
     SEHFQKAVED KSRSLNESKI EIERLQSLTE SLTKEHLLLE GELRSLRLEC DDLRQSRSEA
     EHDKNATISE LRSQLQISNA RTLELQGLIS DLQRERGSLR QEIEKFQKQA LEASNRIQES
     KNQCSQVVQE RESLLVKIKV LEQDKARLQR LEDELNRAKV TLEAESRVKQ RLECEKQQIQ
     NDLNQLTSSS GQ
//