ID A0A455AGZ9_PHYMC Unreviewed; 243 AA.
AC A0A455AGZ9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Calcipressin-2 {ECO:0000256|ARBA:ARBA00015789};
DE AltName: Full=Regulator of calcineurin 2 {ECO:0000256|ARBA:ARBA00029914};
GN Name=RCAN2 {ECO:0000313|RefSeq:XP_028335063.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028335063.1};
RN [1] {ECO:0000313|RefSeq:XP_028335063.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028335063.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC binding to the catalytic domain of calcineurin A. Could play a role
CC during central nervous system development.
CC {ECO:0000256|ARBA:ARBA00024927}.
CC -!- SIMILARITY: Belongs to the RCAN family.
CC {ECO:0000256|ARBA:ARBA00008209}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_028335063.1; XM_028479262.2.
DR AlphaFoldDB; A0A455AGZ9; -.
DR STRING; 9755.ENSPCTP00005011490; -.
DR Ensembl; ENSPCTT00005012697; ENSPCTP00005011490; ENSPCTG00005008155.
DR KEGG; pcad:102975337; -.
DR InParanoid; A0A455AGZ9; -.
DR OrthoDB; 2727072at2759; -.
DR Proteomes; UP000248484; Chromosome 18.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:InterPro.
DR CDD; cd12709; RRM_RCAN2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR006931; Calcipressin.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034919; RCAN2_RRM.
DR PANTHER; PTHR10300; CALCIPRESSIN; 1.
DR PANTHER; PTHR10300:SF5; CALCIPRESSIN-2; 1.
DR Pfam; PF04847; Calcipressin; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT REGION 213..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 243 AA; 27279 MW; 048BC6E171873A71 CRC64;
MRGDSYFIGM RSLGQQGHIP EDGGLFLLCC IDRDWAVTRC FTEEAFQAIT DFTDLPNSLF
ACNVHQSVFE GDESKEKFEG LFRTYDDCVT FQLFKSFRRV RINFSNPKSA ARARIELHET
QFRGKKLKLY FAQVQTPETD GDKLHLAPPQ PAKQFLISPP ASPPVGWQPI SDATPVLNYD
LLYAVAKLGP GEKYELHAGT ESTPSVVVHV CDSDIEEEED PKMSPKPKII QTRRPGPPPS
VSN
//
