ID A0A455AKG9_PHYMC Unreviewed; 749 AA.
AC A0A455AKG9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN Name=ZDHHC8 {ECO:0000313|RefSeq:XP_028336344.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028336344.1};
RN [1] {ECO:0000313|RefSeq:XP_028336344.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028336344.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|ARBA:ARBA00023340};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC Evidence={ECO:0000256|ARBA:ARBA00023340};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC ERF2/ZDHHC9 subfamily. {ECO:0000256|ARBA:ARBA00023463}.
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DR RefSeq; XP_028336344.1; XM_028480543.2.
DR AlphaFoldDB; A0A455AKG9; -.
DR Proteomes; UP000248484; Chromosome 19.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF1; PALMITOYLTRANSFERASE ZDHHC8; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW Membrane {ECO:0000256|RuleBase:RU079119};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 132..156
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 168..194
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 86..206
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 278..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 79795 MW; 40C0433A5308A467 CRC64;
MLQCRGLWAG DRRPGSRRVC PWLTRAVSPA VPVYNGILFL FVLANFSMAT FMDPGVFPRA
DEDEDKEDDF RAPLYKNVDV RGIQVRMKWC ATCHFYRPPR CSHCSVCDNC VEDFDHHCPW
VNNCIGRRNY RYFFLFLLSL SAHMVGVVAF GLVYVLNHAE GLGAAHTAIT MAVMCVAGLF
FIPVIGLTGF HVVLVTRGRT TNEQVTGKFR GGVNPFTRGC YGNVEHVLCS PLAPRYVVEP
PRLPLAARLK PPFLRPELLE RAAPLKVKLS DNGLKAGLGH SKSKGSLDRL DEKPLDLGPP
LPPKAEAGTF GSDLQTPRPG SAESALSAQR TSPPTPAMYK FRPAFPTGTK ASFCGPGEQV
TGTDSLTLGE DSIHSLDFAS EPSLDVPDYP PSSLHAAYPP SPPLSAADTF SGALRSLSLK
AASRRGGDHV ALQPLRSEGG PPTPHRGLFA PHALPNRNGS LSYDSLLNPG SPGGHTCPAH
PSAGAASYRS PYLHAGAAGD PPRPPPRSFS PVLGLRPREP SPVRYDNLSR TIMASIQERK
DREERERLLR SQADSLFGDS GVYDAPSSYS LQQASVLSEG PRGPALRCSS RDDLVAGPGF
GGARNPALQA SLSSLSSAVS RAPRTSSSSL QADLANSGAP GARPASGSHR SPVRQVPPSP
PSTPRSPSYV GPKAVAFIQA ELPEPPPSLS VQRDHPQLKT PPSKLNGQSP GLARLGPATG
PTGPSASPAR HTLVKKVSGV GGTTYEISV
//
