ID A0A455AL50_PHYMC Unreviewed; 955 AA.
AC A0A455AL50;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
GN Name=HKDC1 {ECO:0000313|RefSeq:XP_028337370.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028337370.1};
RN [1] {ECO:0000313|RefSeq:XP_028337370.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028337370.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
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DR RefSeq; XP_028337370.1; XM_028481569.1.
DR AlphaFoldDB; A0A455AL50; -.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000248484; Chromosome 20.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2.
DR Gene3D; 3.30.420.40; -; 3.
DR Gene3D; 3.40.367.20; -; 3.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF28; HEXOKINASE HKDC1; 1.
DR Pfam; PF00349; Hexokinase_1; 3.
DR Pfam; PF03727; Hexokinase_2; 2.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 2.
PE 3: Inferred from homology;
KW Allosteric enzyme {ECO:0000256|ARBA:ARBA00022533};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..192
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 199..432
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT DOMAIN 443..545
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 574..670
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 677..910
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 955 AA; 106454 MW; AA5C1EDD52B9E9D4 CRC64;
MRLSDETLLD IMARFQAEMQ KGLGKDTNPT ASVKMLPTFV RAIPDGSENG EFLSLDLGGS
KFRVLKVQVS EEGKRNVQME SQFYPTPNEI IRGNGTELFE YVADCLADFM RTKELMQKKL
PLGLTFSFPC KQTKLEEGVL LSWTKKFKAR GVQGTDVVSS LTNAMRKHKQ DLDVDILALV
NDTVGTMMTC AYDDPYCEVG VIIGTGTNAC YMEDMSNIEL VEGDEGRMCI NTEWGAFGDD
GALEDIRTEF DRELDLGSLN PGKQLFEKMI SGLYLGELVR LILLKMAKAG LLFGGEKSSA
LHIKGKIETR HVAAMEKYKE GLANTREILT DLGLEASEAD CVAVQHVCTV VSFRSANLCA
AALAAILTRL RENKKLVRLR TTVGMDGTLY KIHPQYPKRL HKVVRKLVPN CDVRFLLSES
GSTKGAAMVT AVASRVQAQR KQIDKVLALF RLTREQLVGV RDKMRVELEY GLKRDTHPLA
TVKMLPTYVC GMPDGTEKGK FLALDLGGTN FRVLLVKIRS GRRSVRMYNK IFAIPLEIMQ
GTGEEVNAGQ GVPRSEVPAC HPIQCRPGMT AALSLQLFDH IVQCIADFLD YMGLKGAQLP
LGFTFSFPCR QASIDKGTLI EWTKGFKATD CEGEDVVDML REAIKRRNEF DLDIVAVVND
TVGTMMTCGY EDRNCEVGLI AGTGSNMCYM EEMRNIELVE GDEGKMCINT EWGGFGDNGC
LDDIRTQYDK EVDEGSLNPG KQRYEKMTSG MYLGEIVRQI LIDLTKQGLL FRGQISERLR
TRGIFETKFL SQIESDRLAL LQVRRILQQL GLDSTCEDSI VVKEVCGAVS RRAAELYGAG
LAAIVEKRRE DQGFEHLKIT VGVDGTLYKL HPHFSRILQE TVKELAPRCD VTFMLSEDGS
GKGAALITAV AKRLQQARRE NVKREQKLRS IQPQDEEALI AREPCRKLFM LKDSN
//
