ID A0A455ALM8_PHYMC Unreviewed; 1327 AA.
AC A0A455ALM8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2023, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Sorbin and SH3 domain-containing protein 2 isoform X4 {ECO:0000313|RefSeq:XP_028337570.2};
GN Name=SORBS2 {ECO:0000313|RefSeq:XP_028337570.2};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028337570.2};
RN [1] {ECO:0000313|RefSeq:XP_028337570.2}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028337570.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_028337570.2; XM_028481769.2.
DR Proteomes; UP000248484; Chromosome 20.
DR CDD; cd11920; SH3_Sorbs2_1; 1.
DR CDD; cd11923; SH3_Sorbs2_2; 1.
DR CDD; cd11917; SH3_Sorbs2_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR PANTHER; PTHR14167:SF56; DREBRIN-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02208; Sorb; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 395..456
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 765..824
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 840..901
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1268..1327
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..511
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..573
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1327 AA; 145571 MW; E5EA9BD8A88A0D80 CRC64;
MISFQPYPYS SMRKTEDFNN KPSKVKMNTD SGGCARKRAA MSVTLTSVKR VQSSPNLLAA
GRDSQSPDSA KGFRSVRPNL QEKKSPAQAP LPPPRKESFC SSLITSHTKG DILDQLVTNT
QIPSCTEFFT NKTPLQGTMY SNDESSQTIV YSEESNTTVS YTQKITNPLP PPSSTGPPPK
ADMSTPFLQE DYTQDSQTRR ISTLKLIHNQ DPGSSILFNP PQFSKSVEVP SFRKRPCSPP
PNPVPEIHTA SLSIQIAPLS GHDPESHKQP PELSPETAKI PLQPERQKPA VAAASQSSDC
QVLGIQNLTA NVLESQITVN GNSGGTVSPL SYYQRPFSPS AYSLPGSLNS SIIMQHGRSL
DSSETYPQHA QSLDGGMGSS IPLYRSSEEE KRVTVIKAPH YPGIGPVDES GIPTAIRTTV
DRPKDWYKTM FKQIHMVHKP DDDTDMYNTP YTYNAGLYNS PYSAQSHPAA KTQTYRPLSK
SHSDNGADAF KDASSPVPPP HVPPPVPPLR PRDRSSTEKH DWDPPDRKVD TRKFRSEPRS
IFEYEPGKSS ILQHERPPPL PTTPTPVPRD PGRKPISLSP YGEVTGSPSP PPRTSIPTPS
ACTPALSPIW TDRINPDDID LENEPWYKFF SELEFGRPPP KKALDYVQDH SSGVSNEASL
YQSSIDRSLE RPTSSASMAS DFRKRRKSEP AVGQPRGLGD PTASRTSPGR ADLPGSSTTL
TKSFISSSPS SPSRAKDRES PRSYSSTLTD LGRSVPRERR GTPEKEKLPA KAVYDFKAQT
SKELSFKKGD TVYILRRIDQ NWYEGEHHGR VGIFPISYVE KLTPPEKAQP ARPPPPAQPG
EIGEAVAKYN FSADTNVELS LRKGDRIILL KRVDQNWYEG KIPGTNRQGI FPVSYVEVIK
KNTTKGAEDY PDPPIPHSYS SDRIHSLSSN KLASSEPVPP PLHKASCGPD KGVLQGITPG
WLSLTAKCPL VKPLAPTLPS FRDNFLDELE EFGALVLPAD QAKPNTPEEI TLEIKEDPSV
VLPLPPASAT AKPPSSLLPL PHLGVTSAAA QPPEAALLQD SRKTPQNRFA DLTTMRKGSA
GPEKVPEVLG DKFMTSAHAS VGPLPQTLPV IGEEDEEIYE GVTAGIRRGP ESQEPDALWC
GHDGTEVTPL LHMEEEEEER EADSLKFPIA IPTDPRSPKE DSNAAKTSEE PSSFSSGDRT
STSFPSCLLS SLPFHSSLAT VSDLVPTLSQ PTQPSSSLHL PKYSYQQEIS SPKLKPQRPV
FTHENIQGGG EPFQALYNYT PRNEDELELR ESDVIDVMEK CDDGWFVGTS RRTKFFGTFP
GNYVKRL
//
