ID A0A455AMJ8_PHYMC Unreviewed; 670 AA.
AC A0A455AMJ8;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Transcription factor 7-like 2 isoform X3 {ECO:0000313|RefSeq:XP_028337865.1};
GN Name=TCF7L2 {ECO:0000313|RefSeq:XP_028337865.1};
OS Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Physeteridae; Physeter.
OX NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028337865.1};
RN [1] {ECO:0000313|RefSeq:XP_028337865.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028337865.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
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DR RefSeq; XP_028337865.1; XM_028482064.1.
DR AlphaFoldDB; A0A455AMJ8; -.
DR Proteomes; UP000248484; Chromosome 20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR PANTHER; PTHR10373:SF32; TRANSCRIPTION FACTOR 7-LIKE 2; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM01366; c-clamp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 399..467
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 399..467
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 73779 MW; 157A9AB4E749844D CRC64;
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN ESETNQNSSS
DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS
LSPTARTLHF QSGSTHYSAY KTIEHQIAIQ YLQMKWPLLD VQAGTLQSRQ ALKDARSPSP
AHIVQCPLPC CTQGHDCQHF YPPSDFTVST QVFRDMKRSH SLQKVGEPWC LESNKVPVVQ
HPHHVHPLTP LITYSNEHFT PGNPPPHLPA DVDPKTGIPR PPHPPDISPY YPLSPGTVGQ
IPHPLGWQGQ PVYPITTGGF RHPYPTALTV NASMSSFLSS RFPPHMVPPH HTLHTTGIPH
PAIVTPTVKQ ESSQSDVGSL HSAKHQDSKK EEEKKKPHIK KPLNAFMLYM KEMRAKVVAE
CTLKESAAIN QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKKRKR
DKQPGETNEH SECFLNPCLS LPPITDLSAP KKCRARFGLD QQNNWCGPCR RKKKCVRYIQ
GEGSCLSPPS SDGSLLDSPP SSPNLLGSPP QDAKSQTEQT QPLSLSLKPD PLAHLPMMSP
PPALLLAEAA HGKAPALCAN GALELPPAIP PSPLAQPSTS SLHSHGSLAG TQPQPQPQPQ
PLSLVTKSLE
//
