ID   A0A455AXY8_PHYMC        Unreviewed;       273 AA.
AC   A0A455AXY8;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Protein lifeguard 3 isoform X2 {ECO:0000313|RefSeq:XP_028341079.1, ECO:0000313|RefSeq:XP_028341080.1};
GN   Name=TMBIM1 {ECO:0000313|RefSeq:XP_028341079.1,
GN   ECO:0000313|RefSeq:XP_028341080.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_028341079.1};
RN   [1] {ECO:0000313|RefSeq:XP_028341079.1, ECO:0000313|RefSeq:XP_028341080.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028341079.1,
RC   ECO:0000313|RefSeq:XP_028341080.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000256|RuleBase:RU004379}.
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DR   RefSeq; XP_028341079.1; XM_028485278.2.
DR   RefSeq; XP_028341080.1; XM_028485279.2.
DR   Proteomes; UP000248484; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd10428; LFG_like; 1.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR   PANTHER; PTHR23291:SF35; PROTEIN LIFEGUARD 3; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004379};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU004379};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU004379}.
FT   TRANSMEM        64..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        97..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        127..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        154..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        184..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
SQ   SEQUENCE   273 AA;  30190 MW;  EDAFE0EDBE83F9D4 CRC64;
     MHADGVITPK PPFGQGYAAP CGTSSGHMEG PGQGYDGEER AVSDNFGSGE WSDRKVRHAF
     IRKVYTIISI QLLITVAIIA VFTFVKPVSE FVKANLAVYY ASYAVFLVTY LTLACCQGPR
     RRFPWNIILL TLFTLAMGYM TGTIASVYDT KAVIIAMTIT AVVSISVTIF CFQTKVDFTS
     CTGLFCVLGI VMMVTGIVTA IVLSFQYVYW LHMVYAALGA ICFTLFLAYD TQLVLGNRRY
     TISPEDYITG ALQIYTDIVY IFTFVLQLLG DRN
//